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Publications

Journal Article Review Epublish 7 citations

PubMed: 36615135 DOI: 10.3390/jcm12010335

Innate Immunity in Cardiovascular Diseases-Identification of Novel Molecular Players and Targets.

J Clin Med 12(1)

Authors: Wolfgang Poller, Bettina Heidecker, Enrico Ammirati, Andreas W Kuss, Ana Tzvetkova, Wolfram C Poller, Carsten Skurk, Arash Haghikia

Affiliations

  • Department of Cardiology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 12200 Berlin, Germany.
  • Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.
  • German Center for Cardiovascular Research (DZHK), 12200 Berlin, Germany.
  • De Gasperis Cardio Center and Transplant Center, Niguarda Hospital, 20162 Milano, Italy.
  • Department of Functional Genomics, Interfaculty Institute of Genetics and Functional Genomics, 17475 Greifswald, Germany.
  • Institute of Bioinformatics, University Medicine Greifswald, 17487 Greifswald, Germany.
  • Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Abstract

During the past few years, unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking advantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss the emerging clinical relevance of advanced diagnostics for cardiovascular diseases, including those associated with COVID-19-with a focus on the role of inflammation in cardiomyopathies and arrhythmias. Second, we consider newly identified immunological interactions at organ and system levels which affect cardiovascular pathogenesis. Thus, studies into immune influences arising from the intestinal system are moving towards therapeutic exploitation. Further, powerful new research tools have enabled novel insight into brain-immune system interactions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress-acting through defined brain regions-upon viral and cardiovascular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

MeSH

Sars-Cov-2, Immunogenetics, Brain, Cardiovascular Diseases, Immunity, Immunity, Innate, Gastrointestinal Microbiome, Immunology

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