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Journal Article Epublish 11 citations

PubMed: 36619998 DOI: 10.3389/fmicb.2022.1061879

The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection.

Front Microbiol 13:1061879

Authors: Yang Wang, Yanping Chen, Lina Gu, Lixin Lou, Jian Zhang, Kaiyu Zhang

Affiliations

  • Center of Infectious Disease and Pathogen Biology, Department of Infectious Diseases, The First Hospital of Jilin University, Changchun, China.
  • Department of Tuberculosis, Changchun Infectious Disease Hospital, Changchun, China.
  • Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.
  • Department of Infectious Diseases, Changchun Infectious Disease Hospital, Changchun, China.

Abstract

Background

Under the wave of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variant Omicron epidemic, the number of infectious cases has increased dramatically in Jilin Province, China since March 2022.The clinical features and severity of SARS-CoV-2 Omicron variant infection in tuberculosis (TB) patients are not yet clear.

Methods

Data were obtained from 153 patients with the Omicron variant and TB coinfection and 153 non-TB COVID-19 patients who had been hospitalized at Changchun Infectious Disease Hospital from March to June 2022.

Results

Among these coinfection patients, 17 patients showed COVID-19-related pneumonia on chest imaging and 11 were diagnosed with severe COVID-19. The median duration of SARS-CoV-2 clearance was 13 days. The negative conversion time was associated with age, COVID-19-related pneumonia and antibody IgG. A higher white blood cell count, a lower lymphocyte percentage, a higher CRP level, and a higher D-dimer level were found in the severe group. Age and increased PCT were individual risk factors for the severity of COVID-19. Compared with the non-TB patients, the coinfection patients had higher severity of COVID-19 and the elder coinfection patients had a longer negative conversion time.

Conclusion

This study found an association between age, pneumonia, antibody IgG and RNA negative conversion time in COVID-19 and TB coinfection patients, and age and increased PCT were risk factors for the severity of COVID-19.

MeSH

Infections, Pneumonia, Tuberculosis, Risk Factors, Coinfection, Covid-19, Sars-Cov-2

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