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Journal Article Epublish 12 citations

PubMed: 36660373 DOI: 10.2147/JIR.S394760

The Levels of Anti-SARS-CoV-2 Spike Protein IgG Antibodies Before and After the Third Dose of Vaccination Against COVID-19.

J Inflamm Res 16:145-160

Authors: Małgorzata Łysek-Gładysińska, Magdalena Starz, Agnieszka Borowiec-Sęk, Iwona Sufin, Anna Wieczorek, Magdalena Chrapek, Dorota Zarębska-Michaluk, Patrycja Sufin, Stanisław Głuszek, Wioletta Adamus-Białek

Affiliations

  • Institute of Biology, Jan Kochanowski University, Kielce, Poland.
  • Meduniv Sp. z o.o, Kielce, Poland.
  • Department of Mathematics, Jan Kochanowski University, Kielce, Poland.
  • Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland.

Abstract

Purpose

The COVID-19 pandemic has been going on for almost three years, and so far, many preventive and therapeutic strategies have been developed. The issue of subsequent booster vaccinations is currently being discussed. We aimed to analyze how the third dose of vaccination against COVID-19 correlates with the dynamics of IgG anti-SARS-CoV-2 spike protein antibody levels in a group of healthy people.

Patients and Methods

The prospective study included 93 participants before and after a second booster of COVID-19 vaccination, from whom 4 blood samples were collected at intervals. The levels of IgG anti-SARS-CoV-2 in serum were identified using the chemiluminescent immunoassay specific for the receptor-binding domain (RBD) of the S1 protein. The analysis of the results was performed using appropriate statistical methods, considering p <0.05 as a statistically significant value.

Results

The IgG levels were significantly higher and less diverse after the same follow-up time from the second booster vaccination compared to the first booster. The antibody levels were positively correlated with female, healthcare workers, the elderly and participants with a negative COVID-19 history. Furthermore, the increase in IgG antibodies after the second booster vaccination correlated inversely with the baseline level of antibodies before the vaccination. The latest results showed that antibody levels dropped 1.5-fold after approx. 10 months from the second booster vaccination but still remained at a protective level.

Conclusion

Booster vaccinations seem to better stimulate immune memory, and in the case of borderline IgG level induces the greatest increase in antibodies. It is worth considering the individual parameters of patients and measuring antibodies before vaccination.

MeSH

Sars-Cov-2, Vaccines, Antibodies, Vaccination, Covid-19, Viruses, Immunity, Pandemics, Severe Acute Respiratory Syndrome-Related Coronavirus, Infections

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