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Publications

Journal Article Research Support, Non-U.S. Gov't Epublish 9 citations

PubMed: 36672177 DOI: 10.3390/cells12020244

Influence of SARS-CoV-2 on Adult Human Neurogenesis.

Cells 12(2)

Authors: Tomasz Stępień, Sylwia Tarka, Natalia Chmura, Michał Grzegorczyk, Albert Acewicz, Paulina Felczak, Teresa Wierzba-Bobrowicz

Affiliations

  • Department of Neuropathology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.
  • Chair and Department of Forensic Medicine, Medical University of Warsaw, 02-007 Warsaw, Poland.
  • Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland.
  • Department of Descriptive and Clinical Anatomy, Medical University of Warsaw, 00-001 Warsaw, Poland.

Abstract

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with the onset of neurological and psychiatric symptoms during and after the acute phase of illness. Inflammation and hypoxia induced by SARS-CoV-2 affect brain regions essential for fine motor function, learning, memory, and emotional responses. The mechanisms of these central nervous system symptoms remain largely unknown. While looking for the causes of neurological deficits, we conducted a study on how SARS-CoV-2 affects neurogenesis. In this study, we compared a control group with a group of patients diagnosed with COVID-19. Analysis of the expression of neurogenesis markers showed a decrease in the density of neuronal progenitor cells and newborn neurons in the SARS-CoV-2 group. Analysis of COVID-19 patients revealed increased microglial activation compared with the control group. The unfavorable effect of the inflammatory process in the brain associated with COVID-19 disease increases the concentration of cytokines that negatively affect adult human neurogenesis.

MeSH

Infections, Brain, Cells, Sars Virus, Neurogenesis, Covid-19, Sars-Cov-2

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