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Publications

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Ppublish 94 citations

PubMed: 36695294 DOI: 10.1002/mrm.29572

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging.

Magn Reson Med 89(5):2024-2047

Authors: Thomas Lindner, Divya S Bolar, Eric Achten, Frederik Barkhof, António J Bastos-Leite, John A Detre, Xavier Golay, Matthias Günther, Danny J J Wang, Sven Haller, Silvia Ingala, Hans R Jäger, Geon-Ho Jahng, Meher R Juttukonda, Vera C Keil, Hirohiko Kimura, Mai-Lan Ho, Maarten Lequin, Xin Lou, Jan Petr, Nandor Pinter, Francesca B Pizzini, Marion Smits, Magdalena Sokolska, Greg Zaharchuk, Henk J M M Mutsaerts

Affiliations

  • Department of Diagnostic and Interventional Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
  • Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, San Diego, California, USA.
  • Department of Radiology and Nuclear Medicine, Ghent University, Ghent, Belgium.
  • Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK.
  • Faculty of Medicine, University of Porto, Porto, Portugal.
  • Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • UCL Queen Square Institute of Neurology, University College London, London, UK.
  • University of Bremen, Bremen, Germany.
  • Fraunhofer MEVIS, Bremen, Germany.
  • Mediri GmbH, Heidelberg, Germany.
  • Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • CIMC - Centre d'Imagerie Médicale de Cornavin, Genève, Switzerland.
  • Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
  • Faculty of Medicine of the University of Geneva, Geneva, Switzerland.
  • Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • UCL Queen Square Institute of Neuroradiology, University College London, London, UK.
  • Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
  • Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
  • Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
  • Radiology, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
  • Division Imaging and Oncology, Department of Radiology and Nuclear Medicine, University Medical Center Utrecht and Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • Department of Radiology, Chinese PLA General Hospital, Beijing, China.
  • Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
  • Dent Neurologic Institute, Buffalo, New York, USA.
  • University at Buffalo Neurosurgery, Buffalo, New York, USA.
  • Radiology Institute, Department of Diagnostic and Public Health, University of Verona, Verona, Italy.
  • Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • The Brain Tumour Centre, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
  • Department of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, UK.
  • Stanford University, Stanford, California, USA.

Abstract

This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update and expand on the recommendations provided in the 2015 ASL consensus paper. Although the 2015 consensus paper provided general guidelines for clinical applications of ASL MRI, there was a lack of guidance on disease-specific parameters. Since that time, the clinical availability and clinical demand for ASL MRI has increased. This position paper provides guidance on using ASL in specific clinical scenarios, including acute ischemic stroke and steno-occlusive disease, arteriovenous malformations and fistulas, brain tumors, neurodegenerative disease, seizures/epilepsy, and pediatric neuroradiology applications, focusing on disease-specific considerations for sequence optimization and interpretation. We present several neuroradiological applications in which ASL provides unique information essential for making the diagnosis. This guidance is intended for anyone interested in using ASL in a routine clinical setting (i.e., on a single-subject basis rather than in cohort studies) building on the previous ASL consensus review.

MeSH

Ischemic Stroke, Neuroimaging, Perfusion Magnetic Resonance Imaging

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