Meta-Analysis Systematic Review Journal Article Ppublish 13 citations
PubMed: 36707044 DOI: 10.1016/j.ijid.2023.01.018
The dose- and time-dependent effectiveness and safety associated with COVID-19 vaccination during pregnancy: a systematic review and meta-analysis.
Int J Infect Dis 128:335-346
Authors: Shengyu Wu, Luyao Wang, Jiaqi Dong, Yirong Bao, Xiaohui Liu, Yuhong Li, Xiaohua Liu, Han Xie, Hao Ying
Affiliations
- Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, China.
- Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
- Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
- Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
- Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Abstract
OBJECTIVES
This study aimed to provide guidance for clinical treatment and increase public confidence in COVID-19 vaccines.
METHODS
The Cochrane Library, Embase, PubMed, Web of Science, ClinicalKey, and other COVID-19 datasets were searched from December 2019 to May 2022. Case-control studies and prospective cohort studies of COVID-19 vaccine effectiveness and safety in pregnant women were included.
RESULTS
From day 11 to day 13, after the first dose of the COVID-19 messenger RNA vaccine, the effectiveness was 54% (95% confidence interval: 0.33-0.69). On days 14 to 27, the effectiveness was 59%. There was a 14% increase in vaccine effectiveness 28 days after the first dose was given. The inactivated vaccines showed similar effectiveness. The proportions of placental abruptions, postpartum hemorrhages, miscarriages, stillbirths, premature births, and small for gestational age infants were not significantly different between vaccinated and nonvaccinated pregnant women. Fatigue and fever were also not associated with pregnancy.
CONCLUSION
Our findings affirm that the effectiveness varies for different types of vaccines and is significantly and positively correlated with time in the pregnant population. COVID-19 vaccines have also been deemed safe for pregnant women. Thus, we developed a comprehensive understanding of the role of vaccines in pregnant women.
MeSH
Pregnant Women, Pregnancy, Safety, Parturition, Vaccines, Covid-19 Vaccines, Vaccination, Covid-19, Communicable Diseases
Cited by
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- Knowledge, attitude and practice towards COVID-19 among pregnant women in Africa: A systematic review and meta-analysis. Heliyon, 2024
- The Effectiveness and Influence of COVID-19 Vaccination on Perinatal Individuals and Their Newborns: An Updated Meta-Analysis. Can J Infect Dis Med Microbiol, 2025
- Lack of association between COVID-19 vaccines and miscarriage onset using a case-crossover design. Sci Rep, 2024
- Vaccine effectiveness against mild and severe covid-19 in pregnant individuals and their infants in England: test negative case-control study. BMJ Med, 2025
- Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy. Front Immunol, 2025