Journal Article Epublish 4 citations
PubMed: 36741108 DOI: 10.3389/fpsyt.2023.1064647
Three-dimensional pseudocontinuous arterial spin labeling perfusion imaging shows cerebral blood flow perfusion decline in attention-deficit/hyperactivity disorder children.
Front Psychiatry 14:1064647
Authors: Shilong Tang, Xianfan Liu, Lisha Nie, Fangfang Qian, Wushang Chen, Ling He
Affiliations
- Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
- GE Healthcare, MR Research China, Beijing, China.
Abstract
Purpose
To investigate the feasibility of three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL) perfusion imaging in the brain of children with Attention-deficit/hyperactivity disorder (ADHD).
Methods
A total of 78 ADHD children aged 5-13 years were prospectively selected as the study group, and 89 healthy children matched in age and sex were selected as the control group. All children underwent MRI conventional sequence, 3D-pcASL, and 3D-T1 sequence scans. The brain gray and white matter volume and cerebral blood flow (CBF) perfusion values were obtained by software post-processing, and were compared and analyzed in the two groups to find out their characteristics in the brain of ADHD children.
Results
The total brain volume and total CBF values were lower in ADHD children than in healthy children ( < 0.05); the gray and white matter volumes in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus and other brain regions were lower in ADHD children than in healthy children ( < 0.05); the gray matter CBF values in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus and other brain regions were lower in ADHD children than in healthy children ( < 0.05); the differences between the white matter CBF values of white matter in the said brain regions of ADHD children and healthy children were not statistically significant ( > 0.05); and the CBF values in frontal lobe and caudate nuclei could distinguish ADHD children (AUC > 0.05, < 0.05).
Conclusion
The 3D-pcASL technique showed reduced cerebral perfusion in some brain regions of ADHD children.
MeSH
White Matter, Hippocampus, Frontal Lobe, Blood, Globus Pallidus, Brain, Magnetic Resonance Imaging, Putamen, Caudate Nucleus, Blood Circulation, Perfusion Imaging, Temporal Lobe, Child, Attention Deficit Disorder With Hyperactivity