Journal Article Epublish 5 citations
PubMed: 36770872 DOI: 10.3390/molecules28031204
Immunomodulatory Effects of Cinnamaldehyde in -Infected Wounds.
Molecules 28(3)
Authors: Cristiane Santos Silva E Silva Figueiredo, Patrícia Vieira de Oliveira, Warlison Felipe da Silva Saminez, Roseana Muniz Diniz, Juliana Silva Pereira Mendonça, Lucas Dos Santos Silva, Miria Yasmim Miranda Paiva, Mayara de Santana do Nascimento, Amanda Silva Dos Santos Aliança, Adrielle Zagmignan, João Francisco Silva Rodrigues, Joicy Cortêz de Sá Souza, Marcos Augusto Grigolin Grisotto, Luís Cláudio Nascimento da Silva
Affiliations
- Laboratório de Patogenicidade Microbiana, Universidade Ceuma, São Luís 65075-120, Brazil. Rede de Biodiversidade e Biotecnologia da Amazônia Legal (BIONORTE), São Luís 65075-120, Brazil.
- Laboratório de Patogenicidade Microbiana, Universidade Ceuma, São Luís 65075-120, Brazil.
- Rede de Biodiversidade e Biotecnologia da Amazônia Legal (BIONORTE), São Luís 65075-120, Brazil.
- BD Research Center Ireland Castletroy, Co. V94 V500 Limerick, Ireland.
Abstract
Cinnamaldehyde (CNM) is an essential-oil component with reported anti-infective, anti-inflammatory, and healing effects, making it an interesting compound for the treatment of wound infection. Herein, we evaluated the effects of topical administration of CNM in experimental wounds infected by . mice ( = 12/group) were randomly allocated into three groups (CON: animals with uninfected lesions; Sa: animals with untreated infected lesions; Sa + CNM: animals with infected wounds and treated with CNM). Excisional lesions (64 mm) were induced at the dorsal area followed by the addition of (80 μL of a 1.5 × 10 CFU/mL bacterial suspension). The wounds were treated with CNM (200 μg/wound/day) or vehicle (2% DMSO) for 10 days. Skin samples were taken on the 3 or 10 treatment day for quantification of inflammatory mediators, bacterial load, immunophenotyping, and histological analysis. The treatment with CNM improved the healing process and attenuated the severity of skin lesions infected by . These effects were associated with significant decreases in bacterial loads in CNM-treated wounds. The levels of neutrophils, TNF-α, IL-6, NO, and VEGF were decreased in the lesions treated with CNM. Taken together, these data provide further evidence of the effectiveness of CNM for the treatment of skin infections.
MeSH
Bacterial Infections, Skin, Bacterial Load