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Publications

Journal Article Scoping Review Epublish 1 citation

PubMed: 36816018 DOI: 10.3389/fgene.2023.1002048

Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review.

Front Genet 14:1002048

Authors: Pouria Khani, Mitra Ansari Dezfouli, Farzad Nasri, Maryam Rahemi, Salma Ahmadloo, Hamed Afkhami, Farzane Saeidi, Sergey Tereshchenko, Mohammad Reza Bigdeli, Mohammad Hossein Modarressi

Affiliations

  • Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Department of stem cell technology and tissue regeneration, Faculty of Science, Tehran University, Tehran, Iran.
  • Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
  • Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
  • Department of Medical Microbiology, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran.
  • Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Research Institute of Medical Problems of the North, Federal Research Center "Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences", Krasnoyarsk, Russia.

Abstract

Couples' relationships defined by a complex interaction between the two partners and their intrapersonal traits. Romantic; relationships and love are associated with marital satisfaction and stability, as well as couples' happiness and health. Personality traits influence romantic relationships and, personality influenced by genetical and non-genetically factors. The roles of non-genetically factors such as socioeconomic position and external appearance have revealed in determining the quality of romantic relationships. We; performed a scoping systematic review to assess the association between genetics and epigenetic factors and romantic relationship. Relevant articles were identified by PubMed, EMBASE, Web of Science, Scopus, and the APA PsycInfo searching between inception and 4 June 2022. Different studies evaluated the associated polymorphisms in 15 different genes or chromosomal regions. In the first step; we classified them into four groups: (1) Oxytocin-related signaling pathway (, , and ); (2) Serotonin-related signaling pathway (, , and ); (3) Dopamine and catecholamine-related signaling pathway (, , , , and ); and (4) other genes (, , , and Y-DNA haplogroup D-M55). Then, we evaluated and extracted significant polymorphisms that affect couple adjustment and romantic relationships. Overall, the findings suggest that genetic and epigenetics variants play a key role in marital adjustment and romantic relationships over time.

MeSH

Genetics, Genes