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Journal Article Epublish 10 citations

PubMed: 36835080 DOI: 10.3390/ijms24043646

Bioactive and Physico-Chemical Assessment of Innovative Poly(lactic acid)-Based Biocomposites Containing Sage, Coconut Oil, and Modified Nanoclay.

Int J Mol Sci 24(4)

Authors: Raluca Nicoleta Darie-Niță, Anamaria Irimia, Florica Doroftei, Laura Mihaela Stefan, Andrzej Iwanczuk, Agnieszka Trusz

Affiliations

  • "Petru Poni" Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, 700487 Iasi, Romania.
  • National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, 060031 Bucharest, Romania.
  • Faculty of Environmental Engineering, Wroclaw University of Science and Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wroclaw, Poland.

Abstract

The bioactivity of the versatile biodegradable biopolymer poly(lactic acid) (PLA) can be obtained by combining it with natural or synthetic compounds. This paper deals with the preparation of bioactive formulations involving the melt processing of PLA loaded with a medicinal plant (sage) and an edible oil (coconut oil), together with an organomodifed montmorillonite nanoclay, and an assessment of the resulting structural, surface, morphological, mechanical, and biological properties of the biocomposites. By modulating the components, the prepared biocomposites show flexibility, both antioxidant and antimicrobial activity, as well as a high degree of cytocompatibility, being capable to induce the cell adherence and proliferation on their surface. Overall, the obtained results suggest that the developed PLA-based biocomposites could potentially be used as bioactive materials in medical applications.

MeSH

Antioxidants, Lactic Acid, Coconut Oil

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