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Publications

Journal Article Epublish

PubMed: 36835792 DOI: 10.3390/jcm12041256

Near-Infrared Spectroscopy Demonstrates the Benefit of Erythracytapheresis in Sickle Cell Disease Adult Patients with Cerebral Vasculopathy.

J Clin Med 12(4)

Authors: Suella Martino, Rym Chouk Turki, Fouzia Zouiti, Romain Fort, Sadaf Pakdaman, Stéphanie Forté, Dehbia Menouche, David Calvet, Thomas Rupp, France Pirenne, Pablo Bartolucci

Affiliations

  • Sickle Cell Referral Center, Department of Internal Medicine, Henri Mondor University Hospital, UPEC, APHP, 94000 Creteil, France.
  • Etablissement Français du Sang, ÃŽle-de-France Mondor, 94000 Creteil, France.
  • Department of Internal Medicine, Edouard Herriot University Hospital, 69003 Lyon, France.
  • Division of Hematology and Oncology, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
  • Department of Apheresis, Henri Mondor University Hospital, UPEC, APHP, 94000 Creteil, France.
  • Department of Neurology, Sainte-Anne Hospital, 75014 Paris, France.
  • Interuniversity Laboratory of Human Movement Biology, University Savoie Mont Blanc, 73000 Chambery, France.
  • Laboratoire D'Excellence, GRex, Institut Mondor, INSERM U955 Equipe 2, 94000 Creteil, France.

Abstract

BACKGROUND

Cerebral vasculopathy can induce chronic cerebral hypoperfusion leading to stroke in patients with sickle cell disease (SCD) and is treated by blood exchange transfusion (BET). However, no prospective clinical study has demonstrated the benefit of BET in adults with SCD and cerebral vasculopathy. Near Infrared Spectroscopy (NIRS) is a recent non-invasive method complementary to Magnetic Resonance Imaging (MRI). We evaluated cerebral perfusion using NIRS during erythracytapheresis in patients with SCD with and without steno-occlusive arterial disease.

METHODS

We conducted a monocentric, prospective study in 16 adults with SCD undergoing erythracytapheresis in 2014. Among them, 10 had cerebral steno-occlusive arterial disease. NIRS measured the relative amounts of oxyhemoglobin (OxyHb), deoxyhemoglobin (DeoxyHb) and total hemoglobin (Total Hb) in brain tissue and in muscle.

RESULTS

In cerebral hemispheres associated with steno-occlusive arterial disease, we observed a significant increase of OxyHb and Total Hb during BET, without modification of DeoxyHb.

CONCLUSION

Using NIRS during BET showed that BET improves cerebral perfusion in adult patients with SCD with cerebral vasculopathy.

MeSH

Anemia, Sickle Cell, Cells, Spectroscopy, Near-Infrared, Hemoglobins, Oxyhemoglobins