Journal Article Research Support, N.I.H., Extramural Epublish 38 citations
PubMed: 36854660 DOI: 10.1038/s41467-023-36547-4
Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life.
Nat Commun 14(1):894
Authors: Ousseny Zerbo, G Thomas Ray, Bruce Fireman, Evan Layefsky, Kristin Goddard, Edwin Lewis, Pat Ross, Saad Omer, Mara Greenberg, Nicola P Klein
Affiliations
- Kaiser Permanente Northern California, Vaccine Study Center, Oakland, CA, USA.
- Kaiser Permanente Northern California, Vaccine Study Center, Oakland, CA, USA.
- Yale University, Institute for Global Health, New Haven, CT, USA.
- Department of Internal Medicine (Infectious Diseases), Yale School of Medicine, New Haven, CT, USA.
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
- Obstetrics and Gynecology, Kaiser Permanente Northern California Oakland, Oakland, CA, USA.
- Regional Perinatal Service Center, Kaiser Permanente Northern California, Santa Clara, CA, USA.
Abstract
We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Using Cox regression, the effectiveness of ≥2 doses of COVID-19 vaccine received during pregnancy was 84% (95% confidence interval [CI]: 66, 93), 62% (CI: 39, 77) and 56% (CI: 34,71) during months 0-2, 0-4 and 0- 6 of a child's life, respectively, in the Delta variant period. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: -21,48), 14% (CI: -9,32) and 13% (CI: -3,26), respectively. Over the entire study period, the incidence of hospitalization for COVID-19 was lower during the first 6 months of life among infants of vaccinated mothers compared with infants of unvaccinated mothers (21/100,000 person-years vs. 100/100,000 person-years). Maternal vaccination was protective, but protection was lower during Omicron than during Delta. Protection during both periods decreased as infants aged.
MeSH
Sars-Cov-2, Mothers, Vaccines, Biological Science Disciplines, Vaccination, Covid-19, Severe Acute Respiratory Syndrome-Related Coronavirus, Infant
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