Journal Article Review Epublish 18 citations
PubMed: 36873108 DOI: 10.3389/fnmol.2023.1110975
Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms.
Front Mol Neurosci 16:1110975
Authors: Yu-Ying Zhao, Zi-Jun Wu, Li-Juan Zhu, Tong-Xiang Niu, Bin Liu, Jing Li
Affiliations
- Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China. Tianjin Research Institute of Anesthesiology, Tianjin, China.
- Department of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin, China. Center for Critical Care Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China.
Abstract
Neuropathic pain, which results from damage to the somatosensory nervous system, is a global clinical condition that affects many people. Neuropathic pain imposes significant economic and public health burdens and is often difficult to manage because the underlying mechanisms remain unclear. However, mounting evidence indicates a role for neurogenic inflammation and neuroinflammation in pain pattern development. There is increasing evidence that the activation of neurogenic inflammation and neuroinflammation in the nervous system contribute to neuropathic pain. Altered miRNA expression profiles might be involved in the pathogenesis of both inflammatory and neuropathic pain by regulating neuroinflammation, nerve regeneration, and abnormal ion channel expression. However, the lack of knowledge about miRNA target genes prevents a full understanding of the biological functions of miRNAs. At the same time, an extensive study on exosomal miRNA, a newly discovered role, has advanced our understanding of the pathophysiology of neuropathic pain in recent years. This section provides a comprehensive overview of the current understanding of miRNA research and discusses the potential mechanisms of miRNAs in neuropathic pain.
MeSH
Nervous System, Pain, Exosomes, Genes, Neuralgia, Neurogenic Inflammation, Micrornas
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