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Publications

Journal Article Review Epublish 14 citations

PubMed: 36875108 DOI: 10.3389/fimmu.2023.1127358

The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy.

Front Immunol 14:1127358

Authors: Aliakbar Hasankhani, Abolfazl Bahrami, Bahareh Tavakoli-Far, Setare Iranshahi, Farnaz Ghaemi, Majid Reza Akbarizadeh, Ali H Amin, Bahman Abedi Kiasari, Alireza Mohammadzadeh Shabestari

Affiliations

  • Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
  • Biomedical Center for Systems Biology Science Munich, Ludwig-Maximilians-University, Munich, Germany.
  • Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran. Department of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
  • School of Pharmacy, Shahid Beheshty University of Medical Sciences, Tehran, Iran.
  • Department of Biochemistry, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Department of Pediatric, School of Medicine, Amir al momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran.
  • Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
  • Virology Department, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
  • Department of Dental Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Khorasan Covid-19 Scientific Committee, Mashhad, Iran.

Abstract

Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled inflammatory responses in the host, ultimately leading to hyperinflammation or cytokine storm. Indeed, cytokine storm is a hallmark of SARS-CoV-2 immunopathogenesis, directly related to the severity of the disease and mortality in COVID-19 patients. Considering the lack of any definitive treatment for COVID-19, targeting key inflammatory factors to regulate the inflammatory response in COVID-19 patients could be a fundamental step to developing effective therapeutic strategies against SARS-CoV-2 infection. Currently, in addition to well-defined metabolic actions, especially lipid metabolism and glucose utilization, there is growing evidence of a central role of the ligand-dependent nuclear receptors and peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARβ/δ, and PPARγ in the control of inflammatory signals in various human inflammatory diseases. This makes them attractive targets for developing therapeutic approaches to control/suppress the hyperinflammatory response in patients with severe COVID-19. In this review, we (1) investigate the anti-inflammatory mechanisms mediated by PPARs and their ligands during SARS-CoV-2 infection, and (2) on the basis of the recent literature, highlight the importance of PPAR subtypes for the development of promising therapeutic approaches against the cytokine storm in severe COVID-19 patients.

MeSH

Cytokines, Sars-Cov-2, Cytokine Release Syndrome, Peroxisomes, Covid-19, Immune System Diseases, Therapeutics, Severe Acute Respiratory Syndrome-Related Coronavirus, Ligands, Infections, Peroxisome Proliferator-Activated Receptors

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