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Publications

Letter Research Support, Non-U.S. Gov't Ppublish 4 citations

PubMed: 36882876 DOI: 10.1002/ajh.26904

Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets.

Am J Hematol 98(6):E134-E138

Authors: Eva Gonzalez Barca, Laura Tomás-Roca, Anna Esteve, Marta Rodriguez, Lucía Gato, Ruth Alonso-Alonso, Alejandro Martin Garcia-Sancho, Raul Cordoba, Anna Monter-Rovira, Mariana Bastos-Oreiro, Juan Miguel Bergua Burgues, Maria Jose Sayas, Maria Cruz Viguria Alegria, Jose Javier Sanchez-Blanco, Monica Roig Pellicer, Hugo Daniel Luzardo Henriquez, Raquel de Oña, Maria Elena Cabezudo, Maria Stefania Infante, José Antonio Queizán Hernández, Rebeca Sanz-Pamplona, Oscar Blanco, Ana Mozos, Fina Climent, Miguel Angel Piris

Affiliations

  • Hematology Department, Institut Català d'Oncologia Hospitalet, Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain.
  • Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Medical Oncology Department, B-ARGO Badalona, Catalan Institute of Oncology, Barcelona, Spain.
  • Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Hematology Department, Hospital Clínico Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain.
  • Hematology Department, Fundación Jiménez Díaz, Madrid, Spain.
  • Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Hematology Department, Gregorio Marañon General University Hospital, Madrid, Spain.
  • Hematology Department, Hospital San Pedro Alcántara, Caceres, Spain.
  • Hematology Department, Hospital Universitario Dr. Peset, Valencia, Spain.
  • Hematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Hematology Department, Hospital Morales Messeguer, Murcia, Spain.
  • Hematology Department, Hospital La Fe, Valencia, Spain.
  • Hematology Department, Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain.
  • Hematology Department, MD Anderson Cancer Center, Madrid, Spain.
  • Hematology Department, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain.
  • Hematology Department, Hospital Infanta Leonor, Madrid, Spain.
  • Hematology Department, Hospital General de Segovia, Segovia, Spain.
  • Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, Barcelona, Spain.
  • Pathology Department, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
  • Pathology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Pathology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet De Llobregat, Barcelona, Spain.

Abstract

(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following: Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.

MeSH

Hematology, Lymphoma, T-Cell, Therapeutics, Natural Killer T-Cells, T-Lymphocytes, Genes, B-Lymphocytes, Herpesvirus 4, Human

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