Journal Article Review Epublish 16 citations
PubMed: 36899999 DOI: 10.3390/diagnostics13050854
Confocal Microscopy for Diagnosis and Management of Cutaneous Malignancies: Clinical Impacts and Innovation.
Diagnostics (Basel) 13(5)
Authors: Mehmet Fatih Atak, Banu Farabi, Cristian Navarrete-Dechent, Gennady Rubinstein, Milind Rajadhyaksha, Manu Jain
Affiliations
- Department of Dermatology, New York Medical College, Metropolitan Hospital, New York, NY 10029, USA.
- Department of Dermatology, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile.
- Dermatology and Laser Centre, Los Angeles, CA 91604, USA.
- Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- Dermatology Service, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Abstract
Cutaneous malignancies are common malignancies worldwide, with rising incidence. Most skin cancers, including melanoma, can be cured if diagnosed correctly at an early stage. Thus, millions of biopsies are performed annually, posing a major economic burden. Non-invasive skin imaging techniques can aid in early diagnosis and save unnecessary benign biopsies. In this review article, we will discuss in vivo and ex vivo confocal microscopy (CM) techniques that are currently being utilized in dermatology clinics for skin cancer diagnosis. We will discuss their current applications and clinical impact. Additionally, we will provide a comprehensive review of the advances in the field of CM, including multi-modal approaches, the integration of fluorescent targeted dyes, and the role of artificial intelligence for improved diagnosis and management.
MeSH
Skin, Microscopy, Confocal, Neoplasms, Biopsy, Microscopy, Diagnosis, Skin Neoplasms
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- The Importance of In Vivo Reflectance Confocal Microscopy in a Case of Desmoplastic Melanoma. Life (Basel), 2024
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- Handheld multiphoton and pinhole-free reflectance confocal microscopy enables noninvasive, real-time cross-sectional imaging in skin. Sci Rep, 2024
- Multiple Primary Melanoma: A Five-Year Prospective Single-Center Follow-Up Study of Two MC1R R/R Genotype Carriers. Life (Basel), 2023
- Current and Emerging Insights into the Causes, Immunopathogenesis, and Treatment of Cutaneous Squamous Cell Carcinoma. Cancers (Basel), 2025
- Artificial Intelligence in the Non-Invasive Detection of Melanoma. Life (Basel), 2025