Journal Article Review Epublish 14 citations
PubMed: 36980399 DOI: 10.3390/diagnostics13061091
miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome.
Diagnostics (Basel) 13(6)
Authors: Milena Jankovic, Dejan Nikolic, Ivana Novakovic, Bojana Petrovic, Milan Lackovic, Milena Santric-Milicevic
Affiliations
- Neurology Clinic, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
- Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
- Department of Physical Medicine and Rehabilitation, University Children's Hospital, 11000 Belgrade, Serbia.
- Clinic of Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
- Department of Obstetrics and Gynecology, University Hospital "Dragisa Misovic", 11000 Belgrade, Serbia.
- Institute of Social Medicine, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
- Faculty of Medicine, School of Public Health and Health Management, University of Belgrade, 11000 Belgrade, Serbia.
Abstract
During the last three years, since the emergence of the COVID-19 pandemic, a significant number of scientific publications have focused on resolving susceptibility to the infection, as well as the course of the disease and potential long-term complications. COVID-19 is widely considered as a multisystem disease and a variety of socioeconomic, medical, and genetic/epigenetic factors may contribute to the disease severity and outcome. Furthermore, the SARS-COV-2 infection may trigger pathological processes and accelerate underlying conditions to clinical entities. The development of specific and sensitive biomarkers that are easy to obtain will allow for patient stratification, prevention, prognosis, and more individualized treatments for COVID-19. miRNAs are proposed as promising biomarkers for different aspects of COVID-19 disease (susceptibility, severity, complication course, outcome, and therapeutic possibilities). This review summarizes the most relevant findings concerning miRNA involvement in COVID-19 pathology. Additionally, the role of miRNAs in wide range of complications due to accompanied and/or underlying health conditions is discussed. The importance of understanding the functional relationships between different conditions, such as pregnancy, obesity, or neurological diseases, with COVID-19 is also highlighted.
MeSH
Infections, Pregnancy, Biomarkers, Therapeutics, Obesity, Micrornas, Covid-19
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