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Journal Article Journal Article Epublish 6 citations

PubMed: 37108697 DOI: 10.3390/ijms24087536

In the SARS-CoV-2 Pandora Pandemic: Can the Stance of Premorbid Intestinal Innate Immune System as Measured by Fecal Adnab-9 Binding of p87:Blood Ferritin, Yielding the FERAD Ratio, Predict COVID-19 Susceptibility and Survival in a Prospective Population Database?

Int J Mol Sci 24(8)

Authors: Martin Tobi, Martin H Bluth, Noreen F Rossi, Ereny Demian, Harvinder Talwar, Yosef Y Tobi, Paula Sochacki, Edi Levi, Michael Lawson, Benita McVicker

Affiliations

  • Research and Development Service, Detroit VAMC, 4747 John R Street, Detroit, MI 48602, USA.
  • Blood Transfusion and Donor Services, Department of Pathology, Maimonides Medical Center, 4802 10th Avenue, Brooklyn, NY 11219, USA.
  • School of Medicine, Wayne State University, 540 E Canfield St, Detroit, MI 48201, USA.
  • Division of Nephrology, Department of Physiology, School of Medicine, Wayne State University, 540 E. Canfield Ave. Detroit, MI 48201, USA.
  • Department of Internal Medicine, Pennsylvania State University College of Medicine, 700 HMC Cres Rd. Hershey, PA 17033, USA.
  • Department of Thoracic Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
  • Department of Pathology, Detroit VAMC, 4747 John R Street, Detroit, MI 48602, USA.
  • Division of Gastroenterology and Hepatology, University of California at Sacramento, Sacramento, CA 95819, USA.
  • Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA.
  • Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Abstract

SARS-CoV-2 severity predictions are feasible, though individual susceptibility is not. The latter prediction allows for planning vaccination strategies and the quarantine of vulnerable targets. Ironically, the innate immune response (InImS) is both an antiviral defense and the potential cause of adverse immune outcomes. The competition for iron has been recognized between both the immune system and invading pathogens and expressed in a ratio of ferritin divided by p87 (as defined by the Adnab-9 ELISA stool-binding optical density, minus the background), known as the FERAD ratio. Associations with the FERAD ratio may allow predictive modeling for the susceptibility and severity of disease. We evaluated other potential COVID-19 biomarkers prospectively. Patients with PCR+ COVID-19 tests (Group 1; n = 28) were compared to three other groups. In Group 2 (n = 36), and 13 patients displayed COVID-19-like symptoms but had negative PCR or negative antibody tests. Group 3 (n = 90) had no symptoms and were negative when routinely PCR-tested before medical procedures. Group 4 (n = 2129) comprised a pool of patients who had stool tests and symptoms, but their COVID-19 diagnoses were unknown; therefore, they were chosen to represent the general population. Twenty percent of the Group 4 patients (n = 432) had sufficient data to calculate their FERAD ratios, which were inversely correlated with the risk of COVID-19 in the future. In a case report of a neonate, we studied three biomarkers implicated in COVID-19, including p87, Src (cellular-p60-sarcoma antigen), and Abl (ABL-proto-oncogene 2). The InImS of the first two were positively correlated. An inverse correlation was found between ferritin and lysozyme in serum ( < 0.05), suggesting that iron could have impaired an important innate immune system anti-viral effector and could partially explain future COVID-19 susceptibility.

MeSH

Diabetes Mellitus, Sars-Cov-2, Blood, Biomarkers, Signs And Symptoms, Covid-19, Ferritins, Immune System, Muramidase, Sex, Pandemics, Severe Acute Respiratory Syndrome-Related Coronavirus

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