Journal Article Epublish 3 citations
PubMed: 37367649 DOI: 10.3390/md21060324
Influence of Intestinal Barrier on Alleviating an Increase in Blood Pressure by Sodium Alginate Intake in 2-Kidney, 1-Clip Renovascular Hypertensive Rats.
Mar Drugs 21(6)
Authors: Saki Maruyama, Yukiko Segawa, Ayaka Harui, Kanae Yamamoto, Hiroko Hashimoto, Tomoko Osera, Nobutaka Kurihara
Affiliations
- Hygiene and Preventive Medicine, Graduate School of Home Economics, Kobe Women's University, 2-1 Higashisuma-Aoyama, Suma, Kobe 654-8585, Japan.
- Faculty of Cookery and Confectionery, Osaka Seikei College, 10-62 Aikawa, Higashiyodogawa, Osaka 533-0007, Japan.
- Faculty of Nutrition, Osaka Seikei College, 10-62 Aikawa, Higashiyodogawa, Osaka 533-0007, Japan.
- Department of Nutrition and Health Sciences, Toyo University, 1-1-1 Izumino, Ora-gun, Itakura-machi 374-0193, Gunma, Japan.
Abstract
Sodium alginate (SALG) is a substance derived from brown seaweed that has been shown to reduce blood pressure (BP). However, its effects on renovascular hypertension caused by 2-kidney, 1-clip (2K1C) are not yet clear. Previous research suggests that hypertensive rats have increased intestinal permeability, and that SALG improves the gut barrier in inflammatory bowel disease mouse models. Therefore, the goal of this study was to determine whether the antihypertensive effects of SALG involve the intestinal barrier in 2K1C rats. Rats were fed either a 1.0% SALG diet or a control diet for six weeks after being subjected to 2K1C surgery or a sham operation. The systolic BP was measured weekly, and the mean arterial BP was measured at the end of the study. Intestinal samples were taken for analysis, and plasma lipopolysaccharide (LPS) levels were measured. The results showed that BP in 2K1C rats was significantly higher than in SHAM rats when fed CTL, but not when fed SALG. The gut barrier in 2K1C rats was improved by SALG intake. Plasma LPS levels also differed depending on the animal model and diet. In conclusion, dietary SALG may alleviate 2K1C renovascular hypertension by altering the gut barrier.
MeSH
Hypertension, Renovascular, Kidney, Pharmaceutical Preparations, Alginates, Diet, Blood Pressure