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Journal Article Research Support, Non-U.S. Gov't Epublish 6 citations

PubMed: 37391748 DOI: 10.1186/s12905-023-02443-8

Combined oral antibiotics and intrauterine perfusion can improve in vitro fertilization and embryo transfer pregnancy outcomes in patients with chronic endometritis and repeated embryo implantation failure.

BMC Womens Health 23(1):344

Authors: Nana Ma, Jiaxu Li, Junlei Zhang, Yufu Jin, Jiawei Wang, Weili Qin, Fu Hang, Aiping Qin

Affiliations

  • Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Department of Sports Medicine, Southern University of Science And Technology Hospital, Shenzhen, China.
  • Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Abstract

BACKGROUND

The aim of this retrospective study was to investigate whether oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone) are beneficial for patients with repeated implantation failure (RIF) and chronic endometritis (CE) to improve clinical pregnancy outcomes.

METHODS

Patients with RIF and CE were diagnosed using hysteroscopy and histology together. A total of 42 patients were enrolled in the study. All patients received oral antibiotics (doxycycline combined with metronidazole) and 22 patients underwent intrauterine perfusion (gentamicin combined with dexamethasone) immediately after the end of oral antibiotic therapy. Pregnancy outcomes were evaluated during the first in vitro fertilization (IVF) and embryo transfer (ET) cycle.

RESULTS

For the first D3 ET after treatment with oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone), higher embryo implantation rate (30.95% vs. 26.67%, P = 0.0308), clinical pregnancy rate (30% vs. 50%, P < 0.001), live birth rate (33.33% vs. 45.45%, P < 0.0001). No fetal malformations or ectopic pregnancies were observed.

CONCLUSION

We report oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone) as a novel treatment for CE to improve the outcomes of successful pregnancy compared with those of oral antibiotics alone.

MeSH

Fertilization In Vitro, Therapeutics, Embryo Implantation, Doxycycline, Pregnancy Outcome, Aftercare, Dexamethasone, Endometritis, Metronidazole, Embryo Transfer

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