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Journal Article Review Research Support, Non-U.S. Gov't Epublish 27 citations

PubMed: 37424784 DOI: 10.3389/fcimb.2023.1197646

The neuromodulatory effects of flavonoids and gut Microbiota through the gut-brain axis.

Front Cell Infect Microbiol 13:1197646

Authors: Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li

Affiliations

  • Institute of Animal Husbandry and Veterinary, Tibet Academy of Agricultural and Animal Husbandry Sciences, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lhasa, China. School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
  • National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, China.
  • Institute of Animal Husbandry and Veterinary, Tibet Academy of Agricultural and Animal Husbandry Sciences, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lhasa, China.
  • School of Public Health, Lanzhou University, Lanzhou, Gansu, China.

Abstract

Recent investigations show that dietary consumption of flavonoids could potentially confer neuroprotective effects through a variety of direct and indirect mechanisms. Numerous flavonoids have been shown to cross the BBB and accumulate within the central nervous system (CNS). Some of these compounds purportedly counteract the accumulation and deleterious effects of reactive oxygen species, fostering neuronal survival and proliferation by inhibiting neuroinflammatory and oxidative stress responses. Moreover, several studies suggest that gut microbiota may participate in regulating brain function and host behavior through the production and modulation of bioactive metabolites. Flavonoids may shape gut microbiota composition by acting as carbon substrates to promote the growth of beneficial bacteria that produce these neuroprotective metabolites, consequently antagonizing or suppressing potential pathogens. By influencing the microbiota-gut-brain axis through this selection process, flavonoids may indirectly improve brain health. This review examines the current state of research into the relationship between bioactive flavonoids, gut microbiota, and the gut-brain axis.

MeSH

Brain, Cell Biology, Flavonoids, Gastrointestinal Microbiome, Microbiota

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