Journal Article Research Support, Non-U.S. Gov't Epublish 2 citations
PubMed: 37515231 DOI: 10.3390/v15071545
Immunoglobulin A as a Key Immunological Molecular Signature of Post-COVID-19 Conditions.
Viruses 15(7)
Authors: Graziele F Sousa, Raphael M Carpes, Carina A O Silva, Marcela E P Pereira, Amanda C V F Silva, Viktoria A G S Coelho, Evenilton P Costa, Flávia B Mury, Raquel S Gestinari, Jackson Souza-Menezes, Manuela Leal-da-Silva, José L Nepomuceno-Silva, Amilcar Tanuri, Orlando C Ferreira-Júnior, Cintia Monteiro-de-Barros
Affiliations
- Laboratório de Campanha para Testagem e Pesquisa do COVID-19 (LCC), Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Macaé 27965-045, RJ, Brazil.
- Laboratório de Virologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil.
- Cintia Monteiro de Barros, Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Av. São José do Barreto 764, Macaé 27965-045, RJ, Brazil.
Abstract
COVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immunoglobulin profiles, taking into account sex, vaccination, hospitalization, and age. Fatigue and myalgia were the most common symptoms, and lack of vaccination, hospitalization, and neuropsychiatric and metabolic comorbidities were relevant to the development of PCC. Analysis of serological immunoglobulins showed that IgA was higher in PCC patients, especially in the adult and elderly groups. Also, non-hospitalized and hospitalized PCC patients produced high and similar levels of IgA. Our results indicated that the detection of IgA antibodies against SARS-CoV-2 during the course of the disease could be associated with the development of PCC and may be an immunological signature to predict prolonged symptoms in COVID-19 patients.
MeSH
Hospitalization, Vaccines, Virology, Immunoglobulins, Vaccination, Signs And Symptoms, Immunoglobulin A, Covid-19