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Observational Study Journal Article Research Support, Non-U.S. Gov't Epublish 2 citations

PubMed: 37620974 DOI: 10.1186/s12933-023-01959-5

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.

Cardiovasc Diabetol 22(1):221

Authors: Etienne Chazal, Lucas Morin, Sidney Chocron, Philippe Lassalle, Sebastien Pili-Floury, Lucie Salomon du Mont, David Ferreira, Emmanuel Samain, Andrea Perrotti, Guillaume Besch

Affiliations

  • Université de Franche-Comté, CHU Besançon, EA 3920, Département d'Anesthésie Réanimation Chirurgicale, Besançon, F-25000, France.
  • CHU Besançon, Inserm CIC 1431, Besançon, F-25000, France.
  • Université de Franche-Comté, CHU Besançon, EA 3920, Service de Chirurgie Cardiaque, Besançon, F-25000, France.
  • Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d'Infection et d'Immunité de Lille, Équipe immunité pulmonaire, Biothelis, Lille, F-59000, France.
  • Université de Franche-Comté, CHU Besançon, EA 3920, Service de Chirurgie Vasculaire et Endovasculaire, Besançon, F-25000, France.
  • Université de Franche-Comté, CHU Besançon, EA 481 Neuroscience, Département d'Anesthésie Réanimation Chirurgicale, Besançon, F-25000, France.
  • Université de Franche-Comté, CHU Besançon, EA 3920, Département d'Anesthésie Réanimation Chirurgicale, Besançon, F-25000, France.
  • CHU Besançon, Inserm CIC 1431, Besançon, F-25000, France.

Abstract

BACKGROUND

Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients.

METHODS

We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned isolated coronary artery bypass graft surgery were eligible. Postoperative glycemic variability was assessed by calculating the coefficient of variability (CV) of blood glucose measured within 24 (CV) and 48 (CV) hours after surgery. Serum endocan level was measured at 24 (Endocan) and 48 (Endocan) hours after surgery. Pearson's correlation coefficient with 95% confidence interval (95% CI) was calculated between CV and Endocan, and between CV and Endocan.

RESULTS

Data from 177 patients were analyzed. Median CV and CV were 18% (range 7 to 39%) and 20% (range 7 to 35%) respectively. Neither CV nor CV were significantly correlated to Endocan and Endocan respectively (r (95% CI) = 0.150 (0.001 to 0.290; and r (95% CI) = 0.080 (-0.070 to 0.220), respectively).

CONCLUSIONS

Early postoperative glycemic variability within 48 h after planned cardiac surgery does not appear to be correlated with postoperative serum endocan level.

CLINICAL TRIAL REGISTRATION NUMBER

NCT02542423.

MeSH

Blood Glucose, Diabetes Complications, Serum

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