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Publications

Journal Article Review Research Support, Non-U.S. Gov't Epublish 8 citations

PubMed: 37711609 DOI: 10.3389/fimmu.2023.1239572

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents.

Front Immunol 14:1239572

Authors: Patrick Douglas Corrêa Pereira, Daniel Guerreiro Diniz, Emanuel Ramos da Costa, Nara Gyzely de Morais Magalhães, Anderson de Jesus Falcão da Silva, Jéssica Gizele Sousa Leite, Natan Ibraim Pires Almeida, Kelle de Nazaré Cunha, Mauro André Damasceno de Melo, Pedro Fernando da Costa Vasconcelos, José Antonio Picanço Diniz, Dora Brites, Daniel Clive Anthony, Cristovam Wanderley Picanço Diniz, Cristovam Guerreiro-Diniz

Affiliations

  • Ciência e Tecnologia do Pará, Laboratório de Biologia Molecular e Neuroecologia, Instituto Federal de Educação, Bragança, Pará, Brazil.
  • Seção de Hepatologia, Laboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Belém, Pará, Brazil. Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Laboratório de Investigações em Neurodegeneração e Infecção, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Laboratório de Investigações em Neurodegeneração e Infecção, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, Pará, Brazil.
  • Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Pará, Brazil.
  • Seção de Hepatologia, Laboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Belém, Pará, Brazil.
  • Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
  • Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
  • Department of Pharmacology, Laboratory of Experimental Neuropathology, University of Oxford, Oxford, United Kingdom.

Abstract

Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission. Here, we compared the virome of bats, rodents and migratory birds and the molecular mechanisms underlying symptomatic and asymptomatic disease progression. We also explore the influence of the host physiology and environmental influences on RNA virus expression and how it impacts on the whole brain transcriptome of seemingly healthy semipalmated sandpiper () and spotted sandpiper (). Three time points throughout the year were selected to understand the importance of longitudinal surveys in the characterization of the virome. We finally revisited evidence that upstream and downstream regulation of the inflammatory response is, respectively, associated with resistance and tolerance to viral infections.

MeSH

Virus Replication, Immunity, Infections, Immune System Diseases, Virus Diseases, Genes, Viruses

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