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Journal Article Epublish 17 citations

PubMed: 37765453 DOI: 10.3390/plants12183288

Watermelon Rind Mediated Biosynthesis of Bimetallic Selenium-Silver Nanoparticles: Characterization, Antimicrobial and Anticancer Activities.

Plants (Basel) 12(18)

Authors: Amr H Hashem, Gharieb S El-Sayyad, Abdulaziz A Al-Askar, Samy A Marey, Hamada AbdElgawad, Kamel A Abd-Elsalam, Ebrahim Saied

Affiliations

  • Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
  • Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City 12451, Giza, Egypt.
  • Microbiology and Immunology Department, Faculty of Pharmacy, Galala University, New Galala City 43511, Suez, Egypt.
  • Drug Microbiology Lab. Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 13759, Egypt.
  • Department of Botany and Microbiology, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
  • Integrated Molecular Plant Physiology Research (IMPRES), Department of Biology, University of Antwerp, 2020 Antwerp, Belgium.
  • Plant Pathology Research Institute, Agricultural Research Center, Giza 12619, Egypt.

Abstract

One of the most hazardous diseases that influences human health globally is microbial infection. Therefore, bimetallic nanoparticles have received much attention for controlling microbial infections in the current decade. In the present study, bimetallic selenium-silver nanoparticles (Se-Ag NPs) were effectively biosynthesized using watermelon rind WR extract through the green technique for the first time. UV-visible spectroscopy, transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDX) methods were used to characterize the produced NPs. The results indicated that the bimetallic Se-Ag NPs had synergistic antimicrobial activity at low concentrations, which helped to reduce the toxicity of Ag NPs after the bimetallic Se-Ag NPs preparation and increase their great potential. Se-Ag NPs with sizes ranging from 18.3 nm to 49.6 nm were detected by TEM. Se-Ag NP surfaces were uniformly visible in the SEM picture. The cytotoxicity of bimetallic Se-Ag NPs was assessed against the Wi38 normal cell line to check their safety, where the IC was 168.42 µg/mL. The results showed that bimetallic Se-Ag NPs had antibacterial action against , , , , , and with a minimum inhibitory concentration (MIC) of 12.5 to 50 µg/mL. Additionally, bimetallic Se-Ag NPs had promising anticancer activity toward the MCF7 cancerous cell line, where the IC was 21.6 µg/mL. In conclusion, bimetallic Se-Ag NPs were biosynthesized for the first time using WR extract, which had strong antibacterial, antifungal and anticancer properties.

MeSH

Infections, Cells, Nanoparticles, Cell Line

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