Journal Article Review Epublish 2 citations
PubMed: 37781226 DOI: 10.3389/fphys.2023.1232345
Cardio-respiratory interactions in acute asthma.
Front Physiol 14:1232345
Authors: Morgan Caplan, Olfa Hamzaoui
Affiliations
- Service de Médecine Intensive Réanimation, Hôpital Robert Debré, Université de Reims, Reims, France.
- Unité HERVI, Hémostase et Remodelage Vasculaire Post-Ischémie, Reims, France.
Abstract
Asthma encompasses of respiratory symptoms that occur intermittently and with varying intensity accompanied by reversible expiratory airflow limitation. In acute exacerbations, it can be life-threatening due to its impact on ventilatory mechanics. Moreover, asthma has significant effects on the cardiovascular system, primarily through heart-lung interaction-based mechanisms. Dynamic hyperinflation and increased work of breathing caused by a sharp drop in pleural pressure, can affect cardiac function and cardiac output through different mechanisms. These mechanisms include an abrupt increase in venous return, elevated right ventricular afterload and interdependence between the left and right ventricle. Additionally, Pulsus paradoxus, which reflects the maximum consequences of this heart lung interaction when intrathoracic pressure swings are exaggerated, may serve as a convenient bedside tool to assess the severity of acute asthma acute exacerbation and its response to therapy.
MeSH
Heart, Lung, Asthma