Journal Article Review Epublish 6 citations
PubMed: 37791073 DOI: 10.3389/fcell.2023.1258574
Effects of clinical medications on male fertility and prospects for stem cell therapy.
Front Cell Dev Biol 11:1258574
Authors: Peiting Mo, Ziran Zhao, Xinpeng Ke, Yong Fan, Chaohui Li
Affiliations
- Key Laboratory for Major Obstetric Diseases of Guangdong Province, Department of Obstetrics and Gynecology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Abstract
An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug therapy on male fertility are often not well evaluated in clinical practice. Meanwhile, the development of stem cell therapy and exosomes treatment methods may provide a new sight on treating male infertility. This article reviews the influence and mechanism of small molecule medications on male fertility, as well as progress of stem cell and exosomes therapy for male infertility with the purpose on providing suggestions (recommendations) for evaluating the effect of drugs on male fertility (both positive and negative effect on male fertility) in clinical application and providing strategies for diagnosis and treatment of male infertility.
MeSH
Cells, Fertility, Microscopy, Electron, Scanning Transmission, Pharmaceutical Preparations, Infertility, Stem Cells, Drug Therapy, Exosomes, Therapeutics, Infertility, Male, Spermatogenesis