Journal Article Research Support, Non-U.S. Gov't Epublish 1 citation
PubMed: 37808972 DOI: 10.3389/fpubh.2023.1253762
Statistical explanation of the protective effect of four COVID-19 vaccine doses in the general population.
Front Public Health 11:1253762
Authors: Humberto Reyes, Constanza Méndez, Alexis M Kalergis
Affiliations
- Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
- Departamento de Genética Molecular y MicrobiologÃa, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
- Departamento de EndocrinologÃa, Facultad de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Abstract
Objectives
To assess the effectiveness of four doses of the vaccine against SARS-CoV-2 in the general population and the impact of this on the severity of the disease by age group.
Methods
By using data from the health authority public data base, we build statistical models using R and the GAMLSS library to explain the behavior of new SARS-CoV-2 infections, active COVID-19 cases, ICU bed requirement total and by age group, and deaths at the national level.
Results
The four doses of vaccine and at least the interaction between the first and second doses were important explanatory factors for the protective effect against COVID-19. The for new cases per day was 0.5644 and for occupied ICU beds the is 0.9487. For occupied ICU beds for >70 years is 0.9195 and with the interaction between 4 doses as the main factor.
Conclusions
Although the increase in the number of vaccine doses did not adequately explain the decrease in the number of COVID-19 cases, it explained the decrease in ICU admissions and deaths nationwide and by age group.
MeSH
Public Health, Vaccination, Intensive Care Units, Beds, Sars-Cov-2, Covid-19 Vaccines