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Publications

Journal Article Research Support, Non-U.S. Gov't Ppublish 4 citations

PubMed: 37816498 DOI: 10.3803/EnM.2023.1813

The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least.

Endocrinol Metab (Seoul) 38(5):493-503

Authors: Juan Cai, Fenfen Wang, Mengle Shao

Affiliations

  • CAS Key Laboratory of Molecular Virology and Immunology, The Center for Microbes, Development and Health, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
  • Department of Anesthesiology, Critical Care and Pain Medicine, Center for Perioperative Medicine, McGovern Medical School, UT Health Science Center at Houston, Houston, TX, USA.

Abstract

The growing recognition of mitochondria's crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for enabling adipose tissue plasticity in response to various metabolic cues. Effective control of mitochondrial function at the cellular level, not only in thermogenic brown and beige adipocytes but also in energy-storing white adipocytes, exerts a profound influence on adipose homeostasis. Furthermore, mitochondria play a pivotal role in intercellular communication within adipose tissue via production of metabolites with signaling properties. A more comprehensive understanding of mitochondrial regulation within white adipocytes will empower the development of targeted and efficacious strategies to enhance adipose function, leading to advancements in overall metabolic health.

MeSH

Adipocytes, White, Mitochondria, Adipocytes, Tissues, Adipose Tissue, Endocrine System Diseases

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