Journal Article Research Support, Non-U.S. Gov't Ppublish
PubMed: 37857448 DOI: 10.3174/ajnr.A8006
Specificity of Quantitative Functional Brain Mapping with Arterial Spin-Labeling for Preoperative Assessment.
AJNR Am J Neuroradiol 44(11):1302-1308
Authors: Giannina R Iannotti, Isaure Nadin, Vladimira Ivanova, Quentin Tourdot, Agustina M Lascano, Shahan Momjian, Karl L Schaller, Karl O Lovblad, Frederic Grouiller
Affiliations
- From the Division of Neuroradiology, Diagnostic Department (G.R.I. K.O.L.), Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
- Department of Neurosurgery (G.R.I. I.N. V.I. S.M. K.L.S.), Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
- Faculty of Pharmacy (Q.T.), University of Montpellier, Montpellier, France.
- Division of Neurology (A.M.L.), Department of Clinical Neuroscience, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
- Swiss Centre for Affective Sciences (F.G.), University of Geneva, Geneva, Switzerland.
- Center for Biomedical Imaging (F.G.), MRI University of Geneva Cognitive and Affective Neuroimaging Section, Geneva, Switzerland.
- Laboratory of Neurology and Imaging of Cognition (F.G.), Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Abstract
BACKGROUND AND PURPOSE
Arterial spin-labeling is a noninvasive MR imaging technique allowing direct and quantitative measurement of brain perfusion. Arterial spin-labeling is well-established in clinics for investigating the overall cerebral perfusion, but it is still occasionally employed during tasks. The typical contrast for functional MR imaging is blood oxygen level-dependent (BOLD) imaging, whose specificity could be biased in neurologic patients due to altered neurovascular coupling. This work aimed to validate the use of functional ASL as a noninvasive tool for presurgical functional brain mapping. This is achieved by comparing the spatial accuracy of functional ASL with transcranial magnetic stimulation as the criterion standard.
MATERIALS AND METHODS
Twenty-eight healthy participants executed a motor task and received a somatosensory stimulation, while BOLD imaging and arterial spin-labeling were acquired simultaneously. Transcranial magnetic stimulation was subsequently used to define hand somatotopy.
RESULTS
Functional ASL was found more adjacent to transcranial magnetic stimulation than BOLD imaging, with a significant shift along the inferior-to-superior direction. With respect to BOLD imaging, functional ASL was localized significantly more laterally, anteriorly, and inferiorly during motor tasks and pneumatic stimulation.
CONCLUSIONS
Our results confirm the specificity of functional ASL in targeting the regional neuronal excitability. Functional ASL could be considered as a valid supplementary technique to BOLD imaging for presurgical mapping when spatial accuracy is crucial for delineating eloquent cortex.
MeSH
Brain, Transcranial Magnetic Stimulation, Brain Mapping, Radionuclide Imaging