Journal Article Epublish 6 citations
PubMed: 37865774 DOI: 10.1186/s12933-023-02031-y
Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes.
Cardiovasc Diabetol 22(1):285
Authors: Klaudia Bogusz-Górna, Adriana Polańska, Aleksandra Dańczak-Pazdrowska, Ryszard Żaba, Marta Sumińska, Piotr Fichna, Andrzej Kędzia
Affiliations
- Department of Pediatric Diabetes, Auxology, and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
- Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland.
- Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
- Department of Pediatric Diabetes, Auxology, and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
Abstract
AIMS/HYPOTHESIS
The study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes.
METHODS
One hundred sixty children and adolescents aged 6-18, 125 patients with type 1 diabetes, and 35 healthy volunteers were enrolled in the study. We performed a detailed clinical evaluation, anthropometric measurements, nailfold capillaroscopy, and photoplethysmography.
RESULTS
Patients with diabetes had more often abnormal morphology in capillaroscopy (68.60%, p = 0.019), enlarged capillaries (32.6%, p = 0.006), and more often more over five meandering capillaries (20.90%, p = 0.026) compared to healthy controls. Meandering capillaries correlated with higher parameters of nutritional status. In a photoplethysmography, patients with diagnosed neuropathy had a higher percentage of flow disturbance curves (p < 0.001) with a reduced frequency of normal curves (p = 0.050).
CONCLUSIONS
Capillaroscopic and photoplethysmographic examinations are non-invasive, painless, fast, and inexpensive. They are devoid of side effects, and there are no limitations in the frequency of their use and repetition. The usefulness of capillaroscopy and photoplethysmography in the study of microcirculation in diabetic patients indicates the vast application possibilities of these methods in clinical practice.
MeSH
Child, Diabetes Complications, Diabetes Mellitus, Type 1, Capillaries, Microscopic Angioscopy, Photoplethysmography