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Publications

Journal Article Ppublish 3 citations

PubMed: 37874139 DOI: 10.1128/msystems.00726-23

Methylprednisolone therapy induces differential metabolic trajectories in severe COVID-19 patients.

mSystems 8(6):e0072623

Authors: Victor I Mwangi, Rebeca L A Netto, Mayla G S Borba, Gabriel F Santos, Gesiane S Lima, Lucas S Machado, Michael N Yakubu, Fernando F A Val, Vanderson S Sampaio, Marco A Sartim, Hector H F Koolen, Allyson G Costa, Maria C M Toméi, Tiago P Guimarães, Andrea R Chaves, Boniek G Vaz, Marcus V G Lacerda, Wuelton M Monteiro, Luiz G Gardinassi, Gisely C Melo

Affiliations

  • Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas (UEA), Manaus, Amazonas, Brazil.
  • Fundação de Medicina Tropical Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil.
  • Laboratório de Cromatografia e Espectrometria de Massas, Instituto de Química, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
  • Programa de Pós-Graduação em Ciência da Saúde, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
  • Programa de Pós-Graduação em Ciências do Movimento Humano, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
  • Instituto Todos pela Saúde, São Paulo, São Paulo, Brazil.
  • Pró-reitoria de Pesquisa e Pós-graduação, Universidade Nilton Lins, Manaus, Amazonas, Brazil.
  • Grupo de Pesquisa em Metabolômica e Espectrometria de Massas, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.
  • Programa de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
  • Diretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, Amazonas, Brazil.
  • Escola de Enfermagem de Manaus, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
  • Programa de Pós-graduação em Ciências Aplicadas à Hematologia (PPGH-UEA/HEMOAM), Manaus, Amazonas, Brazil.
  • Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brazil.
  • Instituto Leônidas & Maria Deane/Fundação Oswaldo Cruz (ILMD/Fiocruz Amazônia), Manaus, Amazonas, Brazil.

Abstract

The SARS-CoV-2 virus infection in humans induces significant inflammatory and systemic reactions and complications of which corticosteroids like methylprednisolone have been recommended as treatment. Our understanding of the metabolic and metabolomic pathway dysregulations while using intravenous corticosteroids in COVID-19 is limited. This study will help enlighten the metabolic and metabolomic pathway dysregulations underlying high daily doses of intravenous methylprednisolone in COVID-19 patients compared to those receiving placebo. The information on key metabolites and pathways identified in this study together with the crosstalk with the inflammation and biochemistry components may be used, in the future, to leverage the use of methylprednisolone in any future pandemics from the coronavirus family.

MeSH

Adrenal Cortex Hormones, Infections, Microbiological Phenomena, Therapeutics, Methylprednisolone, Metabolomics, Covid-19, Sars-Cov-2

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