Journal Article Review Ppublish 9 citations
PubMed: 37885158 DOI: 10.1080/21645515.2023.2267295
Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity.
Hum Vaccin Immunother 19(3):2267295
Authors: Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk, Emily Konopka, Matthew Bell, David Joyner, Jennifer Marcy, Virginie Tardif, Michele A Kutzler, Roshell Muir, Elias K Haddad
Affiliations
- Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
- Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
- Tower Health, Reading Hospital, West Reading, PA, USA.
- Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA. Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
- Department of Molecular and Cellular Biology, Drexel University College of Medicine, Philadelphia, PA, USA.
- Department of Family, Community, and Preventative Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Abstract
In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has been made in understanding the innate immune response, including cell players and critical signaling pathways, but many questions remain unanswered, including how the innate immune response dictates host/pathogen responses and responses to vaccines. To complicate things further, it is becoming increasingly clear that the innate immune response is not a linear pathway but is formed from complex networks and interactions. To further our understanding of the crosstalk and complexities, systems-level analyses and expanded experimental technologies are now needed. In this review, we discuss the most recent immunoprofiling techniques and discuss systems approaches to studying the global innate immune landscape which will inform on the development of personalized medicine and innovative vaccine strategies.
MeSH
Vaccines, Metabolomics, Vaccinology, Immunity, Immunity, Innate, Communicable Diseases, Infections
Cited by
- Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges. Int J Mol Sci, 2025
- Shared clinical and immunologic features of mRNA vaccines: preliminary results from a comparative clinical study. Front Immunol, 2025
- Editorial to special issue "The power of immunoprofiling supported by computational data integration and machine learning". Hum Vaccin Immunother, 2024