Journal Article Review Epublish 2 citations
PubMed: 37894169 DOI: 10.3390/microorganisms11102511
SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic.
Microorganisms 11(10)
Authors: Waqas Ahmed, Jia Feng, Yifan Zhang, Lukui Chen
Affiliations
- Department of Neurosurgery, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, China. School of Medicine, Southeast University, Nanjing 210009, China.
- Department of Neurosurgery, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, China. Guangdong Second Provincial General Hospital, Guangzhou 510317, China.
- Department of Neurosurgery, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, China.
Abstract
Respiratory viral infections have been found to have a negative impact on neurological functions, potentially leading to significant neurological impairment. The SARS-CoV-2 virus has precipitated a worldwide pandemic, posing a substantial threat to human lives. Growing evidence suggests that SARS-CoV-2 may severely affect the CNS and respiratory system. The current prevalence of clinical neurological issues associated with SARS-CoV-2 has raised significant concerns. However, there needs to be a more comprehensive understanding of the specific pathways by which SARS-CoV-2 enters the nervous system. Based on the available evidence, this review focuses on the clinical neurological manifestations of SARS-CoV-2 and the possible mechanisms by which SARS-CoV-2 invades the brain.
MeSH
Brain, Sars Virus, Pandemics, Covid-19, Sars-Cov-2
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- New mouse model for inducible hACE2 expression enables to dissect SARS-CoV-2 pathology beyond the respiratory system. Mamm Genome, 2025
- SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a Down syndrome in vitro model. Acta Neuropathol, 2025
- Food and medicine homology: a potential nutritional intervention strategy for post-acute COVID-19 syndrome. Front Pharmacol, 2025