Journal Article Epublish 7 citations
PubMed: 37901041 DOI: 10.1093/braincomms/fcad259
A blunted T17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults.
Brain Commun 5(5):fcad259
Authors: Adam D Bachstetter, Jenny Lutshumba, Edric Winford, Erin L Abner, Barbra J Martin, Jordan P Harp, Linda J Van Eldik, Frederick A Schmitt, Donna M Wilcock, Ann M Stowe, Gregory A Jicha, Barbara S Nikolajczyk
Affiliations
- Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA.
- Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.
- Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
- Department of Epidemiology, University of Kentucky, Lexington, KY 40536, USA.
- Department of Neurology, University of Kentucky, Lexington, KY 40536, USA.
- Department of Behavioral Sciences, University of Kentucky, Lexington, KY 40536, USA.
- Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
- Department of Pharmacology and Nutritional Science, and Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA.
Abstract
People with dementia have an increase in brain inflammation, caused in part by innate and adaptive immune cells. However, it remains unknown whether dementia-associated diseases alter neuro-immune reflex arcs to impact the systemic immune system. We examined peripheral immune cells from a community-based cohort of older adults to test if systemic inflammatory cytokine signatures associated with early stages of cognitive impairment. Human peripheral blood mononuclear cells were cultured with monocyte or T-cell-targeted stimuli, and multiplex assays quantitated cytokines in the conditioned media. Following T-cell-targeted stimulation, cells from women with cognitive impairment produced lower amounts of T17 cytokines compared with cells from cognitively healthy women, while myeloid-targeted stimuli elicited similar amounts of cytokines from cells of both groups. This T17 signature correlated with the proportion of circulating CD4+ and CD8+ T cells and plasma glial fibrillary acidic protein and neurofilament light concentrations. These results suggest that decreases in T17 cytokines could be an early systemic change in women at risk for developing dementia. Amelioration of T17s cytokines in early cognitive impairment could, in part, explain the compromised ability of older adults to respond to vaccines or defend against infection.
MeSH
Cytokines, Cells, Dementia, Cognitive Dysfunction, Biomarkers, Cognition Disorders, Sex Characteristics, Immunity, Sex Differences
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- Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage. medRxiv, 2024