Journal Article Epublish 3 citations
PubMed: 37908670 DOI: 10.2147/IJN.S427055
Polysaccharides as Reducing Agents: Self-Assembled Composite Nanoparticles for Integrative Diabetic Wound Therapy.
Int J Nanomedicine 18:6021-6035
Authors: Xiaofei Huang, Lihua Shi, Yin Lin, Cong Zhang, Penghui Liu, Ran Zhang, Qiqi Chen, Xudong Ouyang, Yuanyuan Gao, Yingshuai Wang, Tongyi Sun
Affiliations
- Shandong Key Laboratory of Proteins and Peptides Pharmaceutical Engineering, Shandong Universities Key Laboratory of Biological Medicine, School of Life Science and Technology, Weifang Medical University, Weifang, Shandong, 261053, People's Republic of China.
- School of Pharmacy, Weifang Medical University, Weifang, Shandong, 261053, People's Republic of China.
- School of Life Science and Technology, Weifang Medical University, Weifang, Shandong, 261053, People's Republic of China.
Abstract
Purpose
Diabetic foot ulcers (DFU) are severe complications of diabetes, posing significant health and societal challenges. Elevated levels of reactive oxygen species (ROS) at the ulcer site hinder wound healing in most patients, while individuals with diabetes are also more susceptible to bacterial infections. This study aims to synthesize a comprehensive therapeutic material using polysaccharides from to promote DFU wound healing, reduce ROS levels, and minimize bacterial infections.
Methods
Polysaccharides from were employed as reducing and stabilizing agents to fabricate polysaccharide-based composite particles (PCPs) utilizing silver ions as templates. PCPs were characterized via UV-Vis, TEM, FTIR, XRD, and DLS. The antioxidant, antimicrobial, and cytotoxic properties of PCPs were assessed through in vitro and cellular experiments. The effects and mechanisms of PCPs on wound healing were evaluated using a diabetic ulcer mouse model.
Results
PCPs exhibited spherical particles with an average size of 57.29±22.41 nm and effectively combined polysaccharides' antioxidant capacity with silver nanoparticles' antimicrobial function, showcasing synergistic therapeutic effects. In vitro and cellular experiments demonstrated that PCPs reduced cellular ROS levels by 54% at a concentration of 31.25 μg/mL and displayed potent antibacterial activity at 8 μg/mL. In vivo experiments revealed that PCPs enhanced the activities of superoxide dismutase (SOD) and catalase (CAT), promoting wound healing in DFUs and lowering the risk of bacterial infections.
Conclusion
The synthesized PCPs offer a novel strategy for the comprehensive treatment of DFU. By integrating antioxidant and antimicrobial functions, PCPs effectively promote wound healing and alleviate patient suffering. The present study demonstrates a new strategy for the integrated treatment of diabetic wounds and expands the way for developing and applying the polysaccharide properties of .
MeSH
Polysaccharides, Bacterial Infections, Therapeutics, Nanoparticles, Reducing Agents, Nanomedicine, Ulcer
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