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Journal Article Ppublish 2 citations

PubMed: 37915187 DOI: 10.4093/dmj.2022.0377

Prediabetes Progression and Regression on Objectively- Measured Physical Function: A Prospective Cohort Study.

Diabetes Metab J 47(6):859-868

Authors: Shanhu Qiu, Yiming Zhu, Bo Xie, Wenji Chen, Duolao Wang, Xue Cai, Zilin Sun, Tongzhi Wu

Affiliations

  • Department of General Practice, Institute of Diabetes, Zhongda Hospital, School of Medicine, Southeast University, Nanjing. Research and Education Centre of General Practice, Zhongda Hospital, Southeast University, Nanjing.
  • Department of Endocrinology, Institute of Diabetes, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Department of Nursing Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.

Abstract

BACKGRUOUND

Prediabetes leads to declines in physical function in older adults, but the impact of prediabetes progression or regression on physical function is unknown. This study assessed this longitudinal association, with physical function objectivelymeasured by grip strength, walking speed, and standing balance, based on the Health and Retirement Study enrolling United States adults aged >50 years.

METHODS

Participants with prediabetes were followed-up for 4-year to ascertain prediabetes status alteration (maintained, regressed, or progressed), and another 4-year to assess their impacts on physical function. Weak grip strength was defined as <26 kg for men and <16 kg for women, slow walking speed was as <0.8 m/sec, and poor standing balance was as an uncompleted fulltandem standing testing. Logistic and linear regression analyses were performed.

RESULTS

Of the included 1,511 participants with prediabetes, 700 maintained as prediabetes, 306 progressed to diabetes, and 505 regressed to normoglycemia over 4 years. Grip strength and walking speed were declined from baseline during the 4-year followup, regardless of prediabetes status alteration. Compared with prediabetes maintenance, prediabetes progression increased the odds of developing weak grip strength by 89% (95% confidence interval [CI], 0.04 to 2.44) and exhibited larger declines in grip strength by 0.85 kg (95% CI, -1.65 to -0.04). However, prediabetes progression was not related to impairments in walking speed or standing balance. Prediabetes regression also did not affect any measures of physical function.

CONCLUSION

Prediabetes progression accelerates grip strength decline in aging population, while prediabetes regression may not prevent physical function decline due to aging.

MeSH

Diabetes Mellitus, Aging, Cohort Studies, Walking Speed, Prediabetic State, Walking, Hand Strength