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Publications

Journal Article Review Epublish 33 citations

PubMed: 37951913 DOI: 10.1186/s12935-023-03095-2

Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering.

Cancer Cell Int 23(1):271

Authors: Fatemehsadat Mousavinasab, Ronika Karimi, Sima Taheri, Fatemeh Ahmadvand, Saameh Sanaaee, Sajad Najafi, Masood Soltani Halvaii, Alireza Haghgoo, Marzieh Zamany, Jamal Majidpoor, Mina Khosravifar, Mohammad Baniasadi, Mehrdad Talebi, Abolfazl Movafagh, Seyed Mohsen Aghaei-Zarch, Nastaran Khorram, Poopak Farnia, Kambiz Kalhor

Affiliations

  • Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
  • Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Department of Microbiology, Shahr Qods Branch, Islamic Azad University, Tehran, Iran.
  • Department of Biology, Islamic Azad University, Tehran, Iran.
  • Department of New Science, Faculty of Cellular and Molecular biology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
  • Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
  • Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
  • Shahid Akbarabadi Clinical Research Development Unit, Iran University of medical Science, Tehran, Iran.
  • Department of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
  • Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Department of Basic Sciences, School of Medicine, Bam University of Medical Sciences, Bam, Iran.
  • Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.
  • Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Earth and Planetary Sciences, University of Tennessee, Knoxville, USA.

Abstract

Recent developments in sequencing technology and analytical approaches have allowed researchers to show that the healthy gut microbiome is very varied and capable of performing a wide range of tasks. The importance of gut microbiota in controlling immunological, neurological, and endocrine function is becoming well-recognized. Thereby, numerous inflammatory diseases, including those that impact the gastrointestinal system, as well as less obvious ones, including Rheumatoid arthritis (RA), cancer, gestational diabetes (GD), type 1 diabetes (T1D), and type 2 diabetes (T2D), have been linked to dysbiotic gut microbiota. Microbiome engineering is a rapidly evolving frontier for solutions to improve human health. Microbiome engineering seeks to improve the function of an ecosystem by manipulating the composition of microbes. Thereby, generating potential therapies against metabolic, inflammatory, and immunological diseases will be possible through microbiome engineering. This essay first provides an overview of the traditional technological instruments that might be used for microbiome engineering, such as Fecal Microbiota Transplantation (FMT), prebiotics, and probiotics. Moreover, we will also discuss experimental genetic methods such as Metagenomic Alteration of Gut microbiome by In situ Conjugation (MAGIC), Bacteriophage, and Conjugative plasmids in manipulating intestinal microbiota.

MeSH

Diabetes Mellitus, Genetic Engineering, Gastrointestinal Microbiome, Microbiota

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