Abstract

In recent years, there has been a growing interest in the use of gelatin nanoparticles (GNPs) for the treatment of infectious diseases. The inherent properties of these nanoparticles make them attractive options for drug delivery. Their biocompatibility ensures that they can interact with biological systems without causing adverse reactions, while their biodegradability ensures that they can break down harmlessly in the body once their function is performed. Furthermore, their capacity for controlled drug release ensures that therapeutic agents can be delivered over a sustained period, thereby enhancing treatment efficacy. This review examines the current landscape of GNP-based drug delivery, with a specific focus on its potential applications and challenges in the context of infectious diseases. Key challenges include controlling drug release rates, ensuring nanoparticle stability under physiological conditions, scaling up production while maintaining quality, mitigating potential immunogenic reactions, optimizing drug loading efficiency, and tracking the biodistribution and clearance of GNPs in the body. Despite these hurdles, GNPs hold promising potential in the realm of infectious disease treatment. Ongoing research and innovation are essential to overcome these obstacles and completely harness the potential of GNPs in clinical applications.

MeSH

Communicable Diseases, Pharmaceutical Preparations, Polymers, Therapeutics, Nanoparticles, Gelatin

Cited by

• Sequential Immunizations with Influenza Neuraminidase Protein Followed by Peptide Nanoclusters Induce Heterologous Protection. Viruses, 2024
• Advancements in insulin delivery: the potential of natural polymers for improved diabetes management. Front Bioeng Biotechnol, 2025
• Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of Biofilms. Microorganisms, 2025
• Innovative Strategies for Combating Multidrug-Resistant Tuberculosis: Advances in Drug Delivery Systems and Treatment. Microorganisms, 2025
• Dual Delivery of Cells and Bioactive Molecules for Wound Healing Applications. Molecules, 2025
• Spray-Drying Microencapsulation of Grape Pomace Extracts with Alginate-Based Coatings and Bioaccessibility of Phenolic Compounds. Gels, 2025
• Novel Applications of Natural Biomaterials in Dentistry-Properties, Uses, and Development Perspectives. Materials (Basel), 2025