Preprint Epublish 3 citations
PubMed: 37961225 DOI: 10.1101/2023.10.26.564282
Oxycodone Self-Administration in Female Rats is Enhanced by ∆-tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure.
bioRxiv
Authors: Jacques D Nguyen, Yanabel Grant, Celine Yang, Arnold Gutierrez, Michael A Taffe
Affiliations
- Department of Psychiatry, University of California, San Diego; La Jolla, CA, USA.
- Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Abstract
Epidemiological evidence suggests that the legalization of cannabis may reduce opioid-related harms. Preclinical evidence of neuropharmacological interactions of endogenous cannabinoid and opioid systems prompts further investigation of cannabinoids as potential therapeutics for the non-medical use of opioids. In these studies female rats, previously trained to self-administer oxycodone (0.15 mg/kg/infusion) intravenously in 6 h sessions, were allowed to self-administer oxycodone after exposure to cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC) by vapor inhalation and THC by injection (5.0-20 mg/kg, i.p.). Self-administration was characterized under Progressive Ratio (PR) and Fixed Ratio (FR) 1 schedules of reinforcement in 3 h sessions. THC decreased IVSA of oxycodone in a FR procedure but increased reward seeking in a PR procedure. CBD decreased the IVSA of oxycodone in the FR but not the PR procedure. The results are consistent with an anti-reward effect of CBD but suggest THC acts to increase the reinforcing efficacy of oxycodone in this procedure.
MeSH
Dronabinol, Oxycodone, Reward, Self Administration, Cannabinoids, Cannabidiol