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Journal Article Review Epublish 34 citations

PubMed: 37981718 DOI: 10.1186/s40364-023-00538-w

Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers.

Biomark Res 11(1):100

Authors: Manli Zhou, Xiaoyun He, Cheng Mei, Chunlin Ou

Affiliations

  • Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Departments of Ultrasound Imaging, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Department of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha, 410008, Hunan, China.
  • Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role in tumorigenesis and tumor development through crosstalk between various immune cells and cytokines in the TME. Exosomes are small extracellular vesicles with a diameter of 50-150 nm, that can transfer biological information (e.g., proteins, nucleic acids, and lipids) from secretory cells to recipient cells through the circulatory system, thereby influencing the progression of various human diseases, including cancer. Recent studies have suggested that TAMs-derived exosomes play crucial roles in malignant cell proliferation, invasion, metastasis, angiogenesis, immune responses, drug resistance, and tumor metabolic reprogramming. TAMs-derived exosomes have the potential to be targeted for tumor therapy. In addition, the abnormal expression of non-coding RNAs and proteins in TAMs-derived exosomes is closely related to the clinicopathological features of patients with cancer, and these exosomes are expected to become new liquid biopsy markers for the early diagnosis, prognosis, and monitoring of tumors. In this review, we explored the role of TAMs-derived exosomes in tumorigenesis to provide new diagnostic biomarkers and therapeutic targets for cancer prevention.

MeSH

Cells, Macrophages, Neoplasms, Organelle Biogenesis, Exosomes, Carcinogenesis, Therapeutics, Tumor-Associated Macrophages

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