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Journal Article Ppublish 7 citations

PubMed: 37997550 DOI: 10.1111/dom.15378

Association of five diet scores with severe NAFLD incidence: A prospective study from UK Biobank.

Diabetes Obes Metab 26(3):860-870

Authors: Fanny Petermann-Rocha, Fernanda Carrasco-Marin, Jirapitcha Boonpor, Solange Parra-Soto, Oliver Shannon, Fiona Malcomson, Nathan Phillips, Mahek Jain, Salil Deo, Katherine M Livingstone, Sara E Dingle, John C Mathers, Ewan Forrest, Frederick K Ho, Jill P Pell, Carlos Celis-Morales

Affiliations

  • School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile.
  • Centro de Vida Saludable, Universidad de Concepción, Concepción, Chile.
  • Faculty of Public Health, Kasetsart University, Chalermphrakiat Sakon Nakhon Province Campus, Kasetsart University, Sakon Nakhon, Thailand.
  • Department of Nutrition and Public Health, Universidad del Bío-Bío, Chillán, Chile.
  • Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
  • School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
  • Surgical Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
  • Case School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.
  • Department of Gastroenterology, Glasgow Royal Infirmary, University of Glasgow, Glasgow, UK.
  • Human Performance Laboratory, Education, Physical Activity and Health Research Unit, Universidad Católica del Maule, Talca, Chile.

Abstract

AIM

This study aimed to contrast the associations of five common diet scores with severe non-alcoholic fatty liver disease (NAFLD) incidence.

MATERIALS AND METHODS

In total, 162 999 UK Biobank participants were included in this prospective population-based study. Five international diet scores were included: the 14-Item Mediterranean Diet Adherence Screener (MEDAS-14), the Recommended Food Score (RFS), the Healthy Diet Indicator (HDI), the Mediterranean Diet Score and the Mediterranean-DASH Intervention for Neurodegenerative Delay score. As each score has different measurements and scales, all scores were standardized and categorized into quartiles. Cox proportional hazard models adjusted for confounder factors investigated associations between the standardized quartiles and severe NAFLD incidence.

RESULTS

Over a median follow-up of 10.2 years, 1370 participants were diagnosed with severe NAFLD. When the analyses were fully adjusted, participants in quartile 4 using the MEDAS-14 and RFS scores, as well as those in quartiles 2 and 3 using the HDI score, had a significantly lower risk of severe incident NAFLD compared with those in quartile 1. The lowest risk was observed in quartile 4 for the MEDAS-14 score [hazard ratio (HR): 0.76 (95% confidence interval (CI): 0.62-0.94)] and the RFS score [HR: 0.82 (95% CI: 0.69-0.96)] and as well as in quartile 2 in the HDI score [HR: 0.80 (95% CI: 0.70-0.91)].

CONCLUSION

MEDAS-14, RFS and HDI scores were the strongest diet score predictors of severe NAFLD. A healthy diet might protect against NAFLD development irrespective of the specific approach used to assess diet. However, following these score recommendations could represent optimal dietary approaches to mitigate NAFLD risk.

MeSH

Incidence, Non-Alcoholic Fatty Liver Disease, Diet, Prospective Studies

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