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Publications

Journal Article Review Epublish 16 citations

PubMed: 38003431 DOI: 10.3390/ijms242216241

CRISPR Variants for Gene Editing in Plants: Biosafety Risks and Future Directions.

Int J Mol Sci 24(22)

Authors: Ali Movahedi, Soheila Aghaei-Dargiri, Hongyan Li, Qiang Zhuge, Weibo Sun

Affiliations

  • Department of Biology and the Environment, College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China.
  • Department of Biological Control Research, Iranian Research Institute of Plant Protection, Agricultural Research Education and Extension Organization (AREEO), Tehran 19858-13111, Iran.

Abstract

The CRISPR genome editing technology is a crucial tool for enabling revolutionary advancements in plant genetic improvement. This review shows the latest developments in CRISPR/Cas9 genome editing system variants, discussing their benefits and limitations for plant improvement. While this technology presents immense opportunities for plant breeding, it also raises serious biosafety concerns that require careful consideration, including potential off-target effects and the unintended transfer of modified genes to other organisms. This paper highlights strategies to mitigate biosafety risks and explores innovative plant gene editing detection methods. Our review investigates the international biosafety guidelines for gene-edited crops, analyzing their broad implications for agricultural and biotechnology research and advancement. We hope to provide illuminating and refined perspectives for industry practitioners and policymakers by evaluating CRISPR genome enhancement in plants.

MeSH

Containment Of Biohazards, Risk, Clustered Regularly Interspaced Short Palindromic Repeats, Technology, Genome, Genes, Plant, Gene Editing

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