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Publications

Journal Article Ppublish 3 citations

PubMed: 38018983 DOI: 10.1128/spectrum.01868-23

Healthy diet intervention reverses the progression of NASH through gut microbiota modulation.

Microbiol Spectr 12(1):e0186823

Authors: Suraphan Panyod, Wei-Kai Wu, Meng-Yun Hu, Huai-Syuan Huang, Rou-An Chen, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu, Lee-Yan Sheen

Affiliations

  • Institute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.
  • Center for Food and Biomolecules, National Taiwan University , Taipei, Taiwan.
  • Department of Medical Research, National Taiwan University Hospital , Taipei, Taiwan.
  • Department of Internal Medicine, College of Medicine, National Taiwan University , Taipei, Taiwan.
  • Division of Gastroenterology, University of Pennsylvania, Perelman School of Medicine , Philadelphia, Pennsylvania, USA.
  • Department of Food Science, Rutgers University , New Brunswick, New Jersey, USA.
  • Department of Internal Medicine, National Taiwan University Hospital , Taipei, Taiwan.
  • National Laboratory Animal Center, National Applied Research Laboratories , Taipei, Taiwan.
  • Graduate Institute of Sports Science, National Taiwan Sport University , Taoyuan City, Taiwan.
  • National Taiwan University, National Center for Food Safety Education and Research , Taipei, Taiwan.

Abstract

The link between gut microbiota and diet is crucial in the development of non-alcoholic steatohepatitis (NASH). This study underscores the essential role of a healthy diet in preventing and treating NASH by reversing obesity, lipidemia, and gut microbiota dysbiosis. Moreover, the supplementation of functional food or drug to the diet can provide additional advantages by inhibiting hepatic inflammation through the modulation of the hepatic inflammasome signaling pathway and partially mediating the gut microbiota and lipopolysaccharide signaling pathway. This study highlights the importance of adopting healthy dietary habits in treating NASH and proposes that supplementing with ginger essential oil or obeticholic acid may offer additional benefits. Nonetheless, further clinical studies are necessary to validate these findings.

MeSH

Microbiological Phenomena, Microbiota, Functional Food, Diet, Healthy, Gastrointestinal Microbiome, Non-Alcoholic Fatty Liver Disease

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