System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Epublish 7 citations

PubMed: 38130595 DOI: 10.1093/ofid/ofad599

Association of Chronic Medical Conditions With Severe Outcomes Among Nonpregnant Adults 18-49 Years Old Hospitalized With Influenza, FluSurv-NET, 2011-2019.

Open Forum Infect Dis 10(12):ofad599

Authors: Efemona A Famati, Dawud Ujamaa, Alissa O'Halloran, Pam Daily Kirley, Shua J Chai, Isaac Armistead, Nisha B Alden, Kimberly Yousey-Hindes, Kyle P Openo, Patricia A Ryan, Maya L Monroe, Anna Falkowski, Sue Kim, Ruth Lynfield, Melissa McMahon, Kathy M Angeles, Sarah A Khanlian, Nancy L Spina, Nancy M Bennett, Maria A Gaitán, Eli Shiltz, Krista Lung, Ann Thomas, H Keipp Talbot, William Schaffner, Andrea George, Holly Staten, Catherine H Bozio, Shikha Garg

Affiliations

  • Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • General Dynamics Information Technology, Falls Church, Virginia, USA.
  • California Emerging Infections Program, Oakland, California, USA.
  • Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Colorado Department of Public Health and Environment, Denver, Colorado, USA.
  • Emerging Infections Program, Yale University School of Public Health, New Haven, Connecticut, USA.
  • Georgia Emerging Infections Program, Atlanta, Georgia, USA.
  • Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
  • Emory University School of Medicine, Atlanta, Georgia, USA.
  • Maryland Department of Health, Baltimore, Maryland, USA.
  • Michigan Department of Health and Human Services, Lansing, Michigan, USA.
  • Minnesota Department of Health, St.Paul, Minnesota, USA.
  • New Mexico Emerging Infections Program, Albuquerque, New Mexico, USA.
  • NewYork State Department of Health, Albany, New York, USA.
  • University of Rochester School of Medicine and Dentistry, Rochester, NewYork, USA.
  • Ohio Department of Health, Columbus, Ohio, USA.
  • Oregon Health Authority, Portland, Oregon, USA.
  • Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Salt Lake County Health Department, Salt Lake City, Utah, USA.

Abstract

Background

Older age and chronic conditions are associated with severe influenza outcomes; however, data are only comprehensively available for adults ≥65 years old. Using data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), we identified characteristics associated with severe outcomes in adults 18-49 years old hospitalized with influenza.

Methods

We included FluSurv-NET data from nonpregnant adults 18-49 years old hospitalized with laboratory-confirmed influenza during the 2011-2012 through 2018-2019 seasons. We used bivariate and multivariable logistic regression to determine associations between select characteristics and severe outcomes including intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and in-hospital death.

Results

A total of 16 140 patients aged 18-49 years and hospitalized with influenza were included in the analysis; the median age was 39 years, and 26% received current-season influenza vaccine before hospitalization. Obesity, asthma, and diabetes mellitus were the most common chronic conditions. Conditions associated with a significantly increased risk of severe outcomes included age group 30-39 or 40-49 years (IMV, age group 30-39 years: adjusted odds ratio [aOR], 1.25; IMV, age group 40-49 years: aOR, 1.36; death, age group 30-39 years: aOR, 1.28; death, age group 40-49 years: aOR, 1.69), being unvaccinated (ICU: aOR, 1.18; IMV: aOR, 1.25; death: aOR, 1.48), and having chronic conditions including extreme obesity and chronic lung, cardiovascular, metabolic, neurologic, or liver diseases (ICU: range aOR, 1.22-1.56; IMV: range aOR, 1.17-1.54; death: range aOR, 1.43-2.36).

Conclusions

To reduce the morbidity and mortality associated with influenza among adults aged 18-49 years, health care providers should strongly encourage receipt of annual influenza vaccine and lifestyle/behavioral modifications, particularly among those with chronic medical conditions.

MeSH

Diabetes Mellitus, Hospitalization, Vaccines, Aged, Influenza, Human, Influenza Vaccines, Intensive Care Units

Cited by