Journal Article Review Epublish 2 citations
PubMed: 38139212 DOI: 10.3390/ijms242417383
Myeloproliferative Neoplasms: Contemporary Review and Molecular Landscape.
Int J Mol Sci 24(24)
Authors: Muftah Mahmud, Swati Vasireddy, Krisstina Gowin, Akshay Amaraneni
Affiliations
- Department of Medicine, Midwestern University Internal Medicine Residency Consortium, Cottonwood, AZ 86326, USA.
- Department of Medicine, University of Arizona Health Sciences, Tucson, AZ 85701, USA.
- Division of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, Tucson, AZ 85701, USA.
Abstract
Myelofibrosis (MF), Myeloproliferative neoplasms (MPNs), and MDS/MPN overlap syndromes have a broad range of clinical presentations and molecular abnormalities, making their diagnosis and classification complex. This paper reviews molecular aberration, epigenetic modifications, chromosomal anomalies, and their interactions with cellular and other immune mechanisms in the manifestations of these disease spectra, clinical features, classification, and treatment modalities. The advent of new-generation sequencing has broadened the understanding of the genetic factors involved. However, while great strides have been made in the pharmacological treatment of these diseases, treatment of advanced disease remains hematopoietic stem cell transplant.
MeSH
Cells, Neoplasms, Classification, Primary Myelofibrosis