System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Review Epublish 11 citations

PubMed: 38188647 DOI: 10.1016/j.mtbio.2023.100913

Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications.

Mater Today Bio 24:100913

Authors: Jianghua Ding, Xinjing Ding, Weifang Liao, Zhihui Lu

Affiliations

  • Department of Hematology & Oncology, Clinical Medical College/Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, 332005, China. Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, 332005, China.
  • Oncology of Department, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 332000, China.
  • Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, 332005, China. Department of Medical Laboratory, Clinical Medical College/Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, 332005, China.

Abstract

Cancer has become an increasingly important public health issue owing to its high morbidity and mortality rates. Although traditional treatment methods are relatively effective, they have limitations such as highly toxic side effects, easy drug resistance, and high individual variability. Meanwhile, emerging therapies remain limited, and their actual anti-tumor effects need to be improved. Nanotechnology has received considerable attention for its development and application. In particular, artificial nanocarriers have emerged as a crucial approach for tumor therapy. However, certain deficiencies persist, including immunogenicity, permeability, targeting, and biocompatibility. The application of erythrocyte-derived materials will help overcome the above problems and enhance therapeutic effects. Erythrocyte-derived materials can be acquired via the application of physical and chemical techniques from natural erythrocyte membranes, or through the integration of these membranes with synthetic inner core materials using cell membrane biomimetic technology. Their natural properties such as biocompatibility and long circulation time make them an ideal choice for drug delivery or nanoparticle biocoating. Thus, red blood cell-derived materials are widely used in the field of biomedicine. However, further studies are required to evaluate their efficacy, in vivo metabolism, preparation, design, and clinical translation. Based on the latest research reports, this review summarizes the biology, synthesis, characteristics, and distribution of red blood cell-derived materials. Furthermore, we provide a reference for further research and clinical transformation by comprehensively discussing the applications and technical challenges faced by red blood cell-derived materials in the treatment of malignant tumors.

MeSH

Cells, Erythrocytes, Blood, Pharmaceutical Preparations, Neoplasms, Research, Blood Cells, Therapeutics, Membranes

Cited by