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Journal Article Epublish 11 citations

PubMed: 38191404 DOI: 10.1186/s12985-024-02285-2

Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome.

Virol J 21(1):11

Authors: Shan-Shan Zhang, Xin Yang, Wan-Xue Zhang, Yiguo Zhou, Ting-Ting Wei, Ning Cui, Juan Du, Wei Liu, Qing-Bin Lu

Affiliations

  • Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
  • State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, China.
  • Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
  • Department of Laboratorial of Science and Technology & Vaccine Research Center, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing, 100191, China.
  • Department of Infectious Diseases, The 154th Hospital, Xinyang, China.
  • Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, China. Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China. Department of Laboratorial of Science and Technology & Vaccine Research Center, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing, 100191, China. Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.

Abstract

BACKGROUND

The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis.

METHODS

A case-control study was conducted in the 154th hospital in China. Totally 88 cases and 22 controls aged ≥ 18 years were enrolled. The cases were selected from laboratory-confirmed SFTS patients. The controls were selected among SFTSV-negative population. Those with diabetes, cancer, hepatitis and other sexually transmitted diseases were excluded in both groups. Fatal cases and survival cases were 1:1 matched. Inter-group differential metabolites and pathways were obtained, and the inter-group discrimination ability was evaluated.

RESULTS

Tryptophan metabolism and phenylalanine metabolism were the top one important metabolism pathway in differentiating the control and case groups, and the survival and fatal groups, respectively. The significant increase of differential metabolites in tryptophan metabolism, including 5-hydroxyindoleacetate (5-HIAA), L-kynurenine (KYN), 5-hydroxy-L-tryptophan (5-HTP), 3-hydroxyanthranilic acid (3-HAA), and the increase of phenylpyruvic acid and decrease of hippuric acid in phenylalanine metabolism indicated the potential metabolic alterations in SFTSV infection. The increase of 5-HIAA, KYN, 5-HTP, phenylpyruvic acid and hippuric acid were involved in the fatal progress of SFTS patients.

CONCLUSIONS

Tryptophan metabolism and phenylalanine metabolism might be involved in the pathogenesis of SFTSV infection. These findings provided new evidence for the pathogenesis and treatment of SFTS.

MeSH

Severe Fever With Thrombocytopenia Syndrome, Tryptophan, Virology, Phenylalanine, Thrombocytopenia, Infections

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