Case Reports Epublish 1 citation
PubMed: 38250590 DOI: 10.3389/fped.2023.1230366
Systemic lupus erythematosus complicated with Fanconi syndrome: a case report and literature review.
Front Pediatr 11:1230366
Authors: Lili Lou, Hui Guo, Meiying Shao
Affiliations
- Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
- West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Abstract
Background
Systemic lupus erythematosus is an autoimmune disease with diverse clinical manifestations. The symptoms of SLE in children are more atypical than adults. Childhood SLE complicated with Fanconi syndrome is extremely rare and even more difficult to diagnose.
Case presentation
This article reports a preschool boy with SLE who presented with renal tubular acidosis, accompanied by weakness in both lower limbs, delayed growth, and malnutrition. It was later found that the patient had the complication of Fanconi syndrome with renal tubular acidosis. Ultimately, renal biopsy confirmed lupus nephritis. The patient was treated with corticosteroid combined with mycophenolate mofetil, hydroxychloroquine, and belimumab. The symptoms of the child were relieved.
Conclusion
Here we report an extremely rare case of childhood SLE complicated with Fanconi syndrome. There has been no similar clinical report. It is necessary to be alert to the possibility of atypical SLE in children to avoid missed diagnosis and misdiagnosis.
MeSH
Lupus Erythematosus, Systemic, Diagnosis, Lupus Nephritis, Child, Acidosis, Renal Tubular, Fanconi Syndrome