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Publications

Journal Article Review Epublish 3 citations

PubMed: 38255167 DOI: 10.3390/biomedicines12010060

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic.

Biomedicines 12(1)

Authors: Luigi Bellocchio, Gianna Dipalma, Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Laura Ferrante, Gaetano Del Vecchio, Giuseppina Malcangi, Andrea Palermo, Andis Qendro, Francesco Inchingolo

Affiliations

  • INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, University of Bordeaux, 33063 Bordeaux, France.
  • Department of Interdisciplinary Medicine, University of Study "Aldo Moro", 70124 Bari, Italy.
  • College of Medicine and Dentistry, Birmingham B4 6BN, UK.
  • Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.

MeSH

Infections, Signs And Symptoms, Oral Health, Pandemics, Covid-19, Sars-Cov-2

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